N. Tanaka, G. P. Cortese, R. M. Barrientos, S. F. Maier, S. L. Patterson. Aging and an immune challenge interact to produce prolonged, but not permanent reductions in hippocampal CA1 late-phase LTP and BDNF in a rodent model of delirium. eNeuro 28 May 2018 https://doi.org/10.1523/ENEURO.0009-18, 2018.
S. L. Patterson. Immune dysregulation and cognitive vulnerability in the aging brain: Interactions of microglia, IL-1b, BDNF and synaptic plasticity. Neuropharmacology 96 (A) (Special Issue on Neuroimmunology and Synaptic Function): 11–18, 2015.
T. R. Chapman, R. M. Barrientos, J. Hoover, S. F. Maier, and S. L. Patterson. Aging and infection reduce expression of specific brain-derived neurotrophic factor mRNAs in hippocampus. Neurobiology of Aging 33(4):832.e1-14, 2012.
R. M. Barrientos, M. G. Frank, N. Y. Crysdale, T. R. Chapman, J. T. Arhendsen, H. E.W. Day, S. Campeau, Linda R. Watkins, S. L. Patterson, S. F. Maier. Little exercise, big effects: Reversing aging and infection-induced memory deficits, and underlying processes. J Neuroscience 31(32):11578-11586, 2011.
G. P. Cortese, R. M. Barrientos, S. F. Maier, and S. L. Patterson. Aging and a peripheral immune challenge interact to reduce levels of BDNF isoforms and activation of PLCγ1 in hippocampal synaptoneurosomes. J. Neuroscience 31(11): 4274-4279, 2011.
T. R. Chapman, R. M. Barrientos, J.T. Ahrendsen, S. F. Maier, and S. L. Patterson. Synaptic correlates of increased cognitive vulnerability with aging: peripheral immune challenge and aging interact to disrupt theta-burst L-LTP in hippocampal area CA1. J. Neuroscience. 30(22): 7598-603, 2010.
R. Bourtchouladze, S. L. Patterson, M.P. Kelly, A. Kreibich E. R. Kandel and T. Abel. Chronically increased Gs signaling disrupts associative and spatial learning. Learning and Memory. 13(6): 745-52, 2006.
A. Barco, S. Patterson*, J.M. Alarcon*, P Gromova, M. Mata-Roig, A. Morozov and E. R. Kandel. *Authors contributed equally to the work – Patterson did the BDNF-related electrophysiology. Gene Expression Profiling of Facilitated L-LTP in VP16-CREB Mice Reveals that BDNF Is Critical for the Maintenance of LTP and Its Synaptic Capture. Neuron. 48: 123-137, 2005.
S. Zakharenko, S. L Patterson, I. Dragatsis, S. O. Zeitlin, S. A. Siegelbaum, E. R. Kandel, A. Morozov. Presynaptic BDNF required for a presynaptic but not postsynaptic component of LTP at hippocampal CA1-CA3 synapses. Neuron 39: 975-990, 2003.
S. L. Patterson, C. Pittenger, A. Morozov, K. C. Martin, H. Scanlin, C. T. Drake and E. R. Kandel. Some forms of cAMP-mediated long lasting potentiation are associated with release of BDNF and nuclear translocation of MAP kinase. Neuron 32:123-140, 2001.
C. T. Drake, T. A. Milner, and S. L. Patterson. Ultrastructural localization of full-length TrkB immunoreactivity in rat hippocampus suggests multiple roles in modulating activity-dependent synaptic plasticity. J. Neuroscience 19(18):8009-8026, 1999.
S. L. Patterson, T. Abel, T. A. S. Deuel, K. C. Martin, J. C. Rose and E. R. Kandel. Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice. Neuron 16:1137-1145, 1996.
S. L. Patterson, M. S. Grady and M. Bothwell. NGF and FGF-like activity in cerebrospinal fluid of brain injured human patients. Brain Research 605:43-49, 1993.
S. L. Patterson, L. M. Grover, P. A. Schwartzkroin and M. Bothwell. Activity dependent changes in neurotrophin expression in rat hippocampal slices – induction of LTP in CA1 evokes increases in BDNF and NT-3 mRNAs. Neuron 9:1081-1088, 1992.