Selected Publications

N. Tanaka, G. P. Cortese, R. M. Barrientos, S. F. Maier, S. L. Patterson.  Aging and an immune challenge interact to produce prolonged, but not permanent reductions in hippocampal CA1 late-phase LTP and BDNF in a rodent model of delirium. eNeuro  28 May 2018, 2018.

S. L. Patterson. Immune dysregulation and cognitive vulnerability in the aging brain: Interactions of microglia, IL-1b, BDNF and synaptic plasticity. Neuropharmacology 96 (A) (Special Issue on Neuroimmunology and Synaptic Function): 11–18,  2015.

T. R. Chapman, R. M. Barrientos, J. Hoover, S. F. Maier, and S. L. Patterson. Aging and infection reduce expression of specific brain-derived neurotrophic factor mRNAs in hippocampus. Neurobiology of Aging 33(4):832.e1-14, 2012.

R. M. Barrientos, M. G. Frank, N. Y. Crysdale, T. R. Chapman, J. T. Arhendsen, H. E.W. Day, S. Campeau, Linda R. Watkins, S. L. Patterson, S. F. Maier. Little exercise, big effects: Reversing aging and infection-induced memory deficits, and underlying processes. J Neuroscience 31(32):11578-11586, 2011.

G. P. Cortese, R. M. Barrientos, S. F. Maier, and S. L. Patterson. Aging and a peripheral immune challenge interact to reduce levels of BDNF isoforms and activation of PLCγ1 in hippocampal synaptoneurosomes. J. Neuroscience 31(11): 4274-4279, 2011.

T. R. Chapman, R. M. Barrientos, J.T. Ahrendsen, S. F. Maier, and S. L. Patterson. Synaptic correlates of increased cognitive vulnerability with aging: peripheral immune challenge and aging interact to disrupt theta-burst L-LTP in hippocampal area CA1. J. Neuroscience. 30(22): 7598-603, 2010.

R. Bourtchouladze, S. L. Patterson, M.P. Kelly, A. Kreibich E. R. Kandel and T. Abel. Chronically increased Gs signaling disrupts associative and spatial learning. Learning and Memory. 13(6): 745-52, 2006.

A. Barco, S. Patterson*, J.M. Alarcon*, P Gromova, M. Mata-Roig, A. Morozov and E. R. Kandel. *Authors contributed equally to the work – Patterson did the BDNF-related electrophysiology. Gene Expression Profiling of Facilitated L-LTP in VP16-CREB Mice Reveals that BDNF Is Critical for the Maintenance of LTP and Its Synaptic Capture. Neuron. 48: 123-137, 2005.

S. Zakharenko, S. L Patterson, I. Dragatsis, S. O. Zeitlin, S. A. Siegelbaum, E. R. Kandel, A. Morozov. Presynaptic BDNF required for a presynaptic but not postsynaptic component of LTP at hippocampal CA1-CA3 synapses. Neuron 39: 975-990, 2003.

S. L. Patterson, C. Pittenger, A. Morozov, K. C. Martin, H. Scanlin, C. T. Drake and E. R. Kandel. Some forms of cAMP-mediated long lasting potentiation are associated with release of BDNF and nuclear translocation of MAP kinase. Neuron 32:123-140, 2001.

C. T. Drake, T. A. Milner, and S. L. Patterson. Ultrastructural localization of full-length TrkB immunoreactivity in rat hippocampus suggests multiple roles in modulating activity-dependent synaptic plasticity. J. Neuroscience 19(18):8009-8026, 1999.

S. L. Patterson, T. Abel, T. A. S. Deuel, K. C. Martin, J. C. Rose and E. R. Kandel. Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice. Neuron 16:1137-1145, 1996.

S. L. Patterson, M. S. Grady and M. Bothwell. NGF and FGF-like activity in cerebrospinal fluid of brain injured human patients. Brain Research 605:43-49, 1993.

S. L. Patterson, L. M. Grover, P. A. Schwartzkroin and M. Bothwell. Activity dependent changes in neurotrophin expression in rat hippocampal slices – induction of LTP in CA1 evokes increases in BDNF and NT-3 mRNAs. Neuron 9:1081-1088, 1992.