Yah-el Har-el, PhD

Research Assistant Professor of Instruction

I’m working on wound healing applications using soy protein and have been assisting in other projects in the lab including our orthopedic fixation devices and bioprinting applications. I’ve recently also worked with creating prosthetic ossicles for the ear.

Research Interests

  • Wound Healing
  • Orthopedic Fixation Devices
  • Prosthetic Ear Ossicles

Published Work

Publications

Michael Phelan, Aratrik Guha, Brandon Harrison, George Moukarzel, Abigail Tetteh, Yah-el Har-el and Ruth Ochia. Design thinking concepts in Undergraduate Engineering Capstone Projects. Accepted  to American Society of Engineering Education.

Azadeh Timnak, Jonathan A. Gerstenhaber, Kang Dong, Yah-el Har-el, Peter I. Lelkes. Gradient porous fibrous scaffolds: A novel approach to improving cell penetration in electrospun scaffolds. Biomed Mater. 2018 Aug 21. doi: 10.1088/1748-605X/aadbbe

Brandon Kamrava, Jonathan Gerstenhaber, Yah-el Har-el, Pamela C. Roehm. Preliminary study of the design of a custom middle ear prosthesis. Otology & Neurotology. 38(6):839-845 (2017)

David I. Hindin, Sogol M. Baharlou, Jonathan A. Gerstenhaber, Tsz Y. Lo, Yah-el Har-el, James P. Bradley, Peter I. Lelkes. Electrospun soy protein scaffolds enhance skin regeneration in a rat wound model. J Am Coll Surg 221(4):e117-e118 (2015)

Yah-el Har-el, Jonathan A. Gerstenhaber, Ross Brodsky, Richard B. Huneke and Peter I. Lelkes. Electrospun soy protein scaffolds as wound dressings: Enhanced reepithelialization in a porcine model of wound healing. Wound Medicine. 5:9-15 (2014)

Leko Lin, Anat Perets, Yah-el Har-el, Devika Varma, Mengyan Li, Philip Lazarovici, Dara L. Woerdeman, Peter I. Lelkes. Alimentary ‘green’ proteins as electrospun scaffolds for skin regenerative engineering. J Tissue Eng Regen Med. doi: 10.1002/term.1493. (2012 Apr 12)[Epub ahead of print]

Guanshu Liu, Matthew Moake, Yah-el Har-el, Chris M. Long, Kannie W.Y. Chan, Amanda Cardona, Muksit Jamil, Piotr Walczak, Assaf A. Gilad, George Sgouros, Peter C.M. van Zijl, Jeff W.M. Bulte, Michael T. McMahon. In vivo multicolor molecular MR imaging using diamagnetic chemical exchange saturation transfer liposomes. Magnetic Medicine in Medicine 67:1106-1113 (2012)

Jason M. Zhao, Yah-el Har-el, Michael T. McMahon, Jinyuan Zhou, A. Dean Sherry, George Sgouros, Jeff W.M. Bulte and Peter C.M. van Zijl. Size-induced enhancement of chemical exchange saturation transfer (CEST) contrast in liposomes. JACS 130:5178-5184 (2008) PMCID: PMC2759111

Yah-el Har-el and Yoshinori Kato. Intracellular delivery of nanocarriers for cancer therapy. Current Nanoscience. 3:329-338 (2007)

Book Chapters

H. Gozde Senel-Ayaz, Yah-el Har-el, Hasan Ayaz, Peter I. Lelkes. Functional tissue engineered three-dimensional scaffolds: Technologies and applications. In: Ying Deng and Jordan Kuiper (ed.) Functional 3-D Tissue Engineering Scaffolds, pp. 175-202. Oxford, UK: Woodhead Publishing.

Justin Hanes, Michelle Dawson, Yah-el Har-el, Junghae Suh, and Jennifer Fiegel. Gene therapy in the lung. In: A. J. Hickey (ed.) Pharmaceutical Inhalation Aerosol Technology, 2nd edition. New York: Marcel Dekker Inc.

Patents

Robotic electroprosessing system and method, US10005219B2, Granted June 26, 2018.

Negative pressure enhanced cellular infiltration into electrospun scaffolds, PCT/US17/55273, pending

Graded porous scaffolds as immunomodulatory wound patches, provisional patent filed, April 2017, US 62/490,148

Portable spinner and methods of use, PCT/US16/54410, pending

Soy-derived bioactive peptides for use in compositions and methods for wound healing, tissue engineering, and regenerative medicine, PCT/US16/43388, pending

Presentations

Yah-el Har-el, Jonathan A. Gerstenhaber and Peter I. Lelkes. Enhanced wound healing by soy-based wound dressings: Side by side comparison with Oasis®. Biomedical Engineering Society Meeting. October 16-19, 2019

Jonathan A. Gerstenhaber, Baran Arig, Madison G. Baltazar, Yah-el Har-el and Peter I. Lelkes. Portable electroblowing device for in situ generation of wound dressings. Biomedical Engineering Society Meeting. October 16-19, 2019

Azadeh Timnak, Yah-el Har-el, Peter I. Lelkes.Macrophage infiltration into macro-porous electrospun scaffolds initiates a reparative inflammatory response. Tissue Engineering and Regenerative Medicine Annual Conference (TERMIS). December 2017

Ruth Ochia, Jamie Bracey, Yah-el Har-el. Non-cognitive factors associated with freshmen undergraduate bioengineering majors. Biomedical Engineering Society Meeting. October 11-14, 2017

Brandon Kamrava, Jonathan A. Gerstenhaber, Yah-el Har-el, Pamela C. Roehm. Preliminary study of the design of a custom middle ear prosthesis. American Otological Society Meeting. May 20-21, 2016

Yah-el Har-el, Jonathan A. Gerstenhaber, Sogol M. Baharlou, Tsz Y. Lo, David Hindin, Peter I. Lelkes. Side by side comparison of electrospun soy-based scaffolds and Oasis® in a rat model of full thickness excisional wound healing. Biomedical Engineering Society Meeting. October 2015

David I. Hindin, Sogol M. Baharlou, Jonathan A. Gerstenhaber, Tsz Y. Lo, Yah-el Har-el, James P. Bradley, Peter I. Lelkes. Electrospun soy protein scaffolds enhance skin regeneration in a rat wound model. American College of Surgeons Clinical Congress. October 2015

Posters

Ruth Ochia and Yah-el Har-el. Rethinking Design Thinking Evaluations in Engineering Capstone Projects. Biomedical Engineering Society Meeting. October 16-19, 2019

Madison Baltazar, Sanaz M. Baharlou, Jonathan A. Gerstenhaber, Yah-el Har-el and Peter I. Lelkes. Development of Nanofibrous Scaffolds of Chitosan Containing Nanoparticles for Bone Repair and Regeneration. Biomedical Engineering Society Meeting. October 16-19, 2019

Brandon Kamrava, Steven Zuniga, Jonathan Gerstenhaber, Yah-el Har-el, Pamela Roehm. Production of a custom middle ear prosthesis using bone cement, Biomedical Engineering Society Meeting. October 17-20, 2018

Ruth Ochia and Yah-el Har-el. Design Thinking Process in Undergraduate BioengineersBiomedical Engineering Society Meeting. October 17-20, 2018

Neha Devaravar, Jonathan A. Gerstenhaber, Yah-el Har-el, Peter I. Lelkes. Histology of wound tissue samples treated with electrospun soy protein scaffolds, Biomedical Engineering Society Meeting. October 17-20, 2018

Azadeh Timnak, Yah-el Har-el, Peter I. Lelkes. Macrophage infiltration into macro-porous electrospun scaffolds initiates a reparative inflammatory response, TERMIS Meeting, Dec 3-6, 2017

Azadeh Timnak, Nahyun Son, Lindsey Yam, Yah-el Har-el, Peter I. Lelkes. Enhanced cellular penetration into porousfibrous implants modulates the immune response in vivo, Biomedical Engineering Society Meeting. October 11-14, 2017

Ruth Ochia, Jamie Bracey and Yah-el Har-el. Non-cognitive factors associated with freshmen undergraduate bioengineers, Biomedical Engineering Society Meeting. October 11-14, 2017

Brandon Kamrava, Jonathan A. Gerstenhaber, SA Zuniga, Pallav Shah, Mamta Amin, J Yang, Yah-el Har-el Pamela C. Roehm. Validity of predicting ossiculoplasty prosthesis size from high-resolution CT and cone beam CT. PA Academy of Otolaryngology-Head and Neck Surgery, June 16-17, 2017

Brandon Kamrava, Jonathan A. Gerstenhaber SA Zuniga, Pallav Shah, Mamta Amin, J Yang, Yah-el Har-el Pamela C. Roehm. Validity of predicting ossiculoplasty prosthesis size from high-resolution CT and cone beam CT. American Otological Society Meeting. April 28-30, 2017

Azadeh Timnak, Jonathan A. Gerstenhaber, Yah-el Har-el, Peter I. Lelkes. Negative pressure improves cell penetration into electrospun scaffolds, Biomedical Engineering Society Meeting. October 2016

Brandon Kamrava, Jonathan A. Gerstenhaber, Yah-el Har-el, Pamela C. Roehm. Preliminary study of the design of a custom middle ear prosthesis. Association for Research in Otolaryngology MidWinter Meeting. February 20-24, 2016

Jonathan A. Gerstenhaber, Yah-el Har-el, Peter I. Lelkes. Electrospinning of personalized scaffolds for wound healing by robotic electrospinner. Biomedical Engineering Society Meeting. October 2015

Yah-el Har-el, Jonathan A. Gerstanhaber, Sogol M. Baharlou, David I. Hindin, Richard B. Huneke, Peter I. Lelkes. Bioactive alimentary protein-based scaffolds (APS) enhance wound healing. PA BIO Life Sciences Future Event. October 2015

Yah-el Har-el, Jonathan A. Gerstenhaber, Sogol M. Baharlou, Tsz Y. Lo, David Hindin, Ross Brodsky, Richard B. Huneke, and Peter I. Lelkes. Bioactive Alimentary Protein-Based Scaffolds (APS) Enhance Wound Healing. BIO International Convention, June 2015

Mario Mata, Yah-el Har-el, and Peter I. Lelkes. Airbrushing of 3D scaffolds for tissue engineering. The 40th Annual Northeast Bioengineering Conference, April 25-27, 2014

Yah-el Har-el, Ross Brodsky, Jonathan A. Gerstenhaber, Richard B. Huneke, Peter I. Lelkes. Electrospun protein scaffolds improve healing in a pig full thickness skin excision wound model. TERMIS November 2013

Jonathan A. Gerstenhaber, Patrick Thompson, Yah-el Har-el, and Peter I. Lelkes. Delta-style robot for electrospinning from rapid prototyped Parts. TERMIS November 2013


Sogol M. Baharlou, Jonathan A. Gerstenhaber,Yah-el Har-el, and Peter I. Lelkes. Controlling electrospun fiber alignment and deposition by using a programmable oscillating auxiliary electrode. TERMIS November 2013

A comprehensive list of oral and poster presentations is available upon request.