Next-generation power electronics feature cross-domain and multi-timescale characteristics and interact with both electric circuits (physical level) and communication networks (cyber level) to dynamically respond to real-time incidents. The low-inertia nature of today’s power systems entails technical concerns that may jeopardize system stability and impact grid services in both normal and contingent operating conditions. We focus on stability enhancement of inverter-dominated low-inertia power grids and deploy hybrid AC and DC architectures to enable flexible energy integration, with a special emphasis on advanced modeling and control (e.g., grid-forming capabilities), AI-aided active stabilization, and cyber and physical hardening of industrial inverters. The hybrid AC and DC architecture with inverter-centric solutions is designed for power grid operation, which is also applicable in other energy systems, such as electric shipboards, more- and all-electric aircraft, among others.