The SERC building is located on the main campus of Temple University, at N 12th St, Philadelphia, PA 19122.
Here is a map of the main campus of Temple University (pdf).
SETPA trains stops at the Temple University train station, located on W. Berks St. between 9th and 10th street. Walk west towards campus (on Berks St) and continue through the walkway under Glatfelter Hall. The SERC building will be on your right as you reach the corner of 12th St.
The nearest Metro stop is the Cecil B. Moore station on the Broad St. Line.
On campus parking information: http://campusoperations.temple.edu/parking-transportation
The Montgomery Garage is very close to SERC.