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We focus on assessment of tissues at the molecular, cellular, and structural level through application of state-of-the-art vibrational spectroscopy, including mid- and near-infrared spectroscopy and spectroscopic imaging, in concert with complementary techniques. Vibrational spectroscopy enables interrogation of structures based on inherent contrast from molecular vibrations. We develop infrared spectral imaging and fiber optic methods for clinical and laboratory assessment of a range of tissues, including bone, cartilage, meniscus, ligament, tendon and cardiovascular tissues, and for developing engineered tissues. In addition, we’re interested in the effect of biological interventions, such as anti-resorptive agents, on bone quality and mechanical properties.