We integrate principles from tissue engineering, biomaterials science, physics, and cell biology to develop model systems and tools that probe cell-matrix interactions for biomedical applications. Using this interdisciplinary approach, we aim to identify and regulate key mechanobiological drivers of a range of physiological and pathological conditions. The Wang Mechanobiology Lab aims to understand how fibronectin, a mechanosensitive extracellular matrix protein, regulates growth factor immobilization, cell adhesion, and cell migration dynamics in physiological and pathophysiological processes. The interdisciplinary approaches used in our research program will enhance our contextual understanding of outside-in signal transduction.