Publications

Poster Presentation

  • C. Sevignani: Improving students’ comprehension of Biology Labs with Audio-Visual materials. Poster presented at the 12th Annual Faculty Conference on Teaching Excellence (January 17, 2014). Temple University, Philadelphia, PA.
  • Poster presented at 12th Faculty Conference 2014 (PDF)

Publications [40] on PubMed [32]

  1. Baffa R, Fassan M, Sevignani C, Vecchione A, Ishii H, Giarnieri E, Iozzo RV, Gomella LG, Croce CM. Fez1/Lzts1 deficient mice are more susceptible to N-butyl-N-(4-hydroxybutil) nitrosamine (BBN) carcinogenesis. Carcinogenesis. 2008 Jan 12 [Epub ahead of print]
  2. Gottardo F, Liu CG, Ferracin M, Calin GA, Fassan M, Bassi P, Sevignani C, Byrne D, Negrini M, Pagano F, Gomella LG, Croce CM, Baffa R. Micro-RNA profiling in kidney and bladder cancers. Urol Oncol. 2007 Sep-Oct;25(5):387-92
  3. Calin GA, Liu CG, Ferracin M, Hyslop T, Spizzo R, Sevignani C, Fabbri M, Cimmino A, Lee EJ, Wojcik SE, Shimizu M, Tili E, Rossi S, Taccioli C, Pichiorri F, Liu X, Zupo S, Herlea V, Gramantieri L, Lanza G, Alder H, Rassenti L, Volinia S, Schmittgen TD, Kipps TJ, Negrini M, Croce CM. Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas. Cancer Cell. 2007 Sep;12(3):215-29
  4. Yendamuri S, Trapasso F, Ferracin M, Cesari R, Sevignani C, Shimizu M, Rattan S, Kuroki T, Dumon KR, Bullrich F, Liu CG, Negrini M, Williams NN, Kaiser LR, Croce CM, Calin GA. Tumor suppressor functions of ARLTS1 in lung cancers. Cancer Res. 2007 Aug 15;67(16):7738-45
  5. *Sevignani C, *Calin GA, Nnadi S, Shimizu M, Davaluri RV, Hyslop T, Demant P, Croce CM, Siracusa L. MicroRNA genes are frequently located near mouse cancer susceptibility loci. Proc Natl Acad Sci USA 2007 May 8; 104(19):017-8022. (*Sevignani C and *Calin GA contributed equally to this work). The MUSMIRSUS (Mus miRNA susceptibility loci) DATABASE was created to compare the positions of microRNA (miRNA) genes with the positions of solid tumor susceptibility and modifier loci in the mouse.
  6. Wlodarski P, Sevignani C, Fernandes MJ, Calabretta B, Wlodarski KH. Tumor induced by Moloney sarcoma virus causes periosteal osteogenesis engaging osteopontin, fibronectin, stromelysin-1 and tenascin. Neoplasma. 2007; 54(2):173-9
  7. Dews, A.Homayouni, D.Yu, D.Murphy, C. Sevignani, E.Wentzel, E.E.Furth, W.M. Lee, G.Enders, J.Mendell, and A.Thomas-Tikhonenko. “Augmentation of tumor angiogenesis by the Myc-activated microRNA cluster”, Nature Genetics. 2006 38(9):1060-1065
  8. Sevignani C, Calin GA, Siracusa LD, Croce CM. Mammalian microRNAs: a small world for fine-tuning gene expression. Mamm Genome. 2006 Mar; 17(3):189-202. Review. Epub 2006 Mar 3
  9. Zanesi N, Aqeilan R, Drusco A, Kaou M, Sevignani C, Costinean S, Bortesi L, La Rocca G, Koldovsky P, Volinia S, Mancini R, Calin G, Scott CP, Pekarsky Y, Croce CM. Effect of rapamycin on mouse chronic lymphocytic leukemia and the development of non-hematopoietic malignancies in Emu-TCL1 transgenic mice. Cancer Res. 2006 Jan 15;66(2):915-20
  10. Calin GA, Ferracin M, Cimmino A, Di Leva G, Shimizu M, Wojcik SE, Iorio MV, Visone R, Sever NI, Fabbri M, Iuliano R, Palumbo T, Pichiorri F, Roldo C, Garzon R, Sevignani C, Rassenti L, Alder H, Volinia S, Liu CG, Kipps TJ, Negrini M, Croce CM. A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N Engl J Med. 2005 Oct 27;353(17):1793-801
  11. *Zanesi N, *Mancini R, *Sevignani C, Vecchione A, Kaou M, Valtieri M, Calin GA, Pekarsky Y, Gnarra JR, Croce CM, Huebner K. Lung cancer susceptibility in Fhit-deficient mice is increased by Vhl haploinsufficiency. Cancer Res. 2005 Aug 1;65(15):6576-82 (*N. Zanesi, *R. Mancini, and *C. Sevignani contributed equally to this work)
  12. *Sarti M, *Sevignani C, Calin GA, Aqeilan R, Shimizu M, Pentimalli F, Picchio MC, Godwin A, Rosenberg A, Drusco A, Negrini M, Croce CM. Adenoviral Transduction of TESTIN Gene into Breast and Uterine Cancer Cell Lines Promotes Apoptosis and Tumor Reduction In vivo. Clin Cancer Res. 2005 Jan 15;11(2 Pt 1):806-13. (*Sarti M and *Sevignani C contributed equally to this work)
  13. Vecchione A, Sevignani C, Giarnieri E, Zanesi N, Ishii H, Cesari R, Fong LY, Gomella LG, Croce CM, Baffa R. Inactivation of the FHIT gene favors bladder cancer development. Clin Cancer Res. 2004 Nov 15;10(22):7607-12
  14. Calin GA, Liu CG, Sevignani C, Ferracin M, Felli N, Dumitru CD, Shimizu M, Cimmino A, Zupo S, Dono M, Dell’Aquila ML, Alder H, Rassenti L, Kipps TJ, Bullrich F, Negrini M, Croce CM. MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias. Proc Natl Acad Sci U S A. 2004 Jul 29 [Epub ahead of print]
  15. Liu CG, Calin GA, Meloon B, Gamliel N, Sevignani C, Ferracin M, Dumitru CD, Shimizu M, Zupo S, Dono M, Alder H, Bullrich F, Negrini M, Croce CM. An oligonucleotide microchip for genome-wide microRNA profiling in human and mouse tissues. Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9740-4. Epub 2004 Jun 21. – PATENT: microRNAs located in or near cancer associated chromosomal features (2002-2005)
  16. Thomas-Tikhonenko A, Viard-Leveugle I, Dews M, Wehrli P, Sevignani C, Yu D, Ricci S, el-Deiry W, Aronow B, Kaya G, Saurat JH, French LE. Myc-transformed epithelial cells down-regulate clusterin, which inhibits their growth in vitro and carcinogenesis in vivo. Cancer Res. 2004 May 1;64(9):3126-36
  17. *Calin GA, *Sevignani C, Dumitru CD, Hyslop T, Noch E, Yendamuri S, Shimizu M, Rattan S, Bullrich F, Negrini M, Croce CM. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2999-3004. Epub 2004 Feb18  (*Calin GA and *Sevignani C contributed equally to this work)
  18. Sevignani C, Calin GA, Cesari R, Sarti M, Ishii H, Yendamuri S, Vecchione A, Trapasso F, Croce CM. Restoration of fragile histidine triad (FHIT) expression induces apoptosis and suppresses tumorigenicity in breast cancer cell lines. Cancer Res. 2003 Mar 15;63(6):1183-7
  19. Turner, M. Ottey, D. B. Zimonjic, M. Potoczek, W. W. Hauck, E. Pequignot, C. Keck-Waggoner, C. Sevignani, M. Aldaz, P. McCue, J. Palazzo, K. Huebner, N. C. Popescu. The FHIT/FRA3B locus and repair deficient cancers. Cancer Res. July 15; 62 (14), 2002
  20. Hunter, D. Yu, M. Gee, C. Ngo, C. Sevignani, M. Goldschmidt, T. Golovkina, S. Evans, W.M. Lee, A.T. Tikhonenko: Systemic inhibition of angiogenesis underlies resistance to tumors during acute toxoplasmosis. J Immunol. 2001 May 15; 166 (10): 5878-81
  21. Janz, C. Sevignani, K. Kenyon, C. Ngo, A.T. Tikhonenko: Activation of Myc oncoprotein leads to increased turnover of thrombospondin-1 mRNA. Nucleic Acids Research 28 (11): 2268-2275, 2000
  22. Cervellera, G. Raschella, G. Santilli, B. Tanno, A. Ventura, C. Mancini, C. Sevignani, B.Calabretta, A. Sala: Expression of Apolipoprotein J gene (Clusterin) is positively regulated by B-Myb in neuroblastoma cells and correlates with advanced disease stages. J Biol Chem Apr 18, 2000
  23. Sevignani, A. Craston, R. Fishel, R.V. Iozzo, B. Calabretta: Spontaneous and mutagen-induced transformation of primary cultures of p53-/-Msh2-/- colonocytes. Cancer Res 59: 5882-5886, 1999 – U.S. Provisional Patent Application entitled: Culture of Msh2-/-p53-/- Colonocytes as in Vitro Cancer Model. Ref.No.: CAL01.P0001 Filed: November 30, 1999
  24. Sevignani, P. Wlodarski, J. Kirillova, K. G. Danielson, E. W. Mercer, R. V. Iozzo, B. Calabretta: Tumorigenic conversion of p53-deficient colon epithelial cells by an activated Ki-ras gene. J Clin Invest 101: 1572-1580, 1998
  25. Wlodarski, M. Wasik, M. Ratajczak, C. Sevignani, G. Hoser, J. Kawiak, B. Calabretta, T. Skorski: Role of p53 in hematopoietic recovery after cytotoxic treatment. Blood 91: 2998-3006, 1998
  26. Motolese, C. Sevignani, A. T. Scacchetti, B. M. Manzini, M. Donini: Levels of eosinophilic cationic protein (ECP) in the serum of patients pazienti affected by chronic idiopathic urticaria. G Ital Dermatol Venereol 131: 83-7, 1996
  27. Pincelli, C. Sevignani, R. Manfredini, A. Grande, F. Fantini, L. Bracci-Laudiero, L. Aloe, S. Ferrari, A. Cossarizza, A. Giannetti: Expression and function of Nerve Growth Factor  and nerve growth factor receptor  on cultured keratinocytes. J Invest Dermatol 103: 13-18, 1994
  28. Pincelli, C. Sevignani, A. Grande, F. Fantini, L. Aloe, A. Giannetti: Normal human keratinocytes express nerve growth factor receptor and proliferate in response to nerve growth factor. J Invest Dermatol 100: 439A, 1993
  29. Pincelli, F. Fantini, L. Giardino, M. Zanni, L. Calzà, C. Sevignani, A. Giannetti: Autoradiographic detection of substance P receptors in normal and psoriatic skin. J Invest Dermatol 101: 301-304, 1993
  30. Pincelli, F. Fantini, P. Romualdi, C. Sevignani, G. Lesa, L. Benassi, A. Giannetti: Substance P is diminished and vasoactive intestinal peptide is augmented in psoriatic lesions and these peptides exert disparate effects on the proliferation of cultured human keratinocytes. J Invest Dermatol 98: 421-427, 1992
  31. Pincelli, F. Fantini, C. Sevignani, A. Baraldi, A. Giannetti: Cutaneous innervation in chronic renal failture patients. An immunohistochemical. Chronica Dermatologica (Suppl) Gennaio-Febbraio: 43-44, 1992
  32. Pincelli, F. Fantini, P. Romualdi, G. Lesa, C. Sevignani, A. Giannetti: Substance P and Vasoactive Intestinal Polypeptide in pathogenesis of psoriatic lesions. Neuropeptides 22,1: 52-53, 1992
  33. Pincelli, F. Fantini, C. Sevignani, L. Benassi, A. Giannetti: Substance P inhibits the vasoactive intestinal polypeptide (VIP)-induced proliferation of cultured human keratinocytes. J Invest Dermatol 98: 538, 1992
  34. Fantini, A. Baraldi, C. Sevignani, A. Spattini, C. Pincelli, A. Giannetti: Cutaneous innervation  in chronic renal failture patients. An immunohistochemical study. Acta Derm-Venereol 72: 102-105, 1992
  35. Pincelli, F. Fantini, L. Benassi, C. Sevignani, A. Giannetti: Effects of vasoactive intestinal polipeptide-related peptides on the proliferation of cultured human keratinocytes. J Invest Dermatol 96: 558, 1991
  36. Fantini, C. Pincelli, C. Sevignani, A. Baraldi, A. Giannetti: Langerhans cells can express neuron-specyfic enolase (N.S.E.) immunoreactivity. Arch Dermatol Res 283: 10-12, 1991
  37. Pincelli, F. Fantini, A. Baraldi, C. Sevignani, A. Spattini, A. Giannetti: Neurochemical markers in skin from patients with uremic pruritus. E.S.D.R. Annual Meeting. Turin June 9-12, 1990. J Invest Dermatol 95: 483, 1990
  38. Bondi, C. Grisolia, C. Sevignani, M. Migaldi: “Farmer’s lung” as a professional disease in agriculture: environmental investigation. Riv. Tuberc. Mal. App. Resp. 22: 299-316, 1990
  39. Kirchlechner, C. Sevignani, M. Bondi: Investigation of pollution in Caldaro Lake (Italy). L’Igiene Moderna 94: 55-67, 1990
  40. Rivasi, G. De Aloysio, R.A. Fano, F. Boselli, C. Sevignani: Use of avidin-biotin-peroxidase complex (A.B.C.) technique for the localization of Human Papilloma Virus  on semithin sections of cytologic cervico-vaginal samples embedded by electron microscopy. The CERVIX and the lower female genital tract 8: 349-354, 1990

 

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