Publications

2017

Tang, Y; Soroush, F; Sheffield, JB; Wang, B; Prabhakarpandian, B & Kiani, MF (2017) A biomimetic microfluidic tumor microenvironment platform mimicking the EPR effect for rapid screening of drug delivery systems. Sci. Rep., In press.

 

Tang, Y; Soroush, F; Tong, Z; Kiani, MF & Wang, B (2017) Targeted multidrug delivery system to overcome chemoresistance in breast cancer.Int. J. Nanomed., 12:671–681.

 

2016

Soroush, F; Zhang, T; King, DJ; Tang, Y; Deosarkar, S; Prabhakarpandian, B; Kilpatrick, LE & Kiani, MF (2016) A Novel microfluidic assay reveals a key role for protein kinase C-delta in regulating human neutrophil-endothelium interaction. J. Leukoc. Biol., 100:1027-1035 [Invited Manuscript] [Featured on the Cover].

 

2015

Deosarkar, SP; Prabhakarpandian, B; Wang, B; Sheffield, JB; Krynska, B & Kiani, MF (2015) A novel dynamic neonatal blood brain barrier on a chip. PLoS ONE, 10(11):e0142725. doi:10.1371/journal.pone.0142725.

 

2014

Lamberti, G; Prabhakarpandian, B; Garson, C; Smith, A; Pant, K; Wang, B & Kiani, MF (2014) Bioinspired microfluidic assay for in vitromodeling of leukocyte-endothelium interactions. Anal. Chem., 86:8344-8351.

 

2013

Lamberti, G; Tang, Y; Prabhakarpandian, B; Wang, Y; Pant, K; Kiani, MF & Wang, B (2013) Adhesive interaction of functionalized particles and endothelium in idealized microvascular networks. Microvasc. Res., 89:107-114.

 

2012

Rosano, J. M., Cheheltani, R., Wang, B., Vora, H., Kiani, M. F., & Crabbe, D. L. (2012, June). Targeted delivery of VEGF after a myocardial infaction reduces collagen deposition and improves cardiac function. Cardiovascular Engineering and Technology, 3(3), 237-247.

 

Cheheltani, R., Rosano, R. M., Wang, B., Sabri, A. K., Pleshko, N., & Kiani, M. F. (2012, May). Fourier transform infrared spectroscopic imaging of cardiac tissue to detect collagen deposition after myocardial infarction. Journal of Biomedial Optics, 17(5), 056014.

 

Venegas, B., Zhu, W., Haloupek, N. B., Lee, J., Zellhart, E., Sugar, I. P., & Kiani, M. F. (2012, May). Cholesterol superlattice modulates CA4P release from liposomes and CA4P cytotoxicity on mammary cancer cells. Biophysical Journal, 102, 2086-2094.

 

2011

Prabhakarpandian, B., Shen, M., Pant, K., & Kiani, M. F. (2011, July 2). Microfluidic devices for modeling cell-cell and particle-cell interactions in the microvasculature. Microvascular Research, 82, 210-220. [pdf]

 

Prabhakarpandian, B., Wang, Y., Rea-Ramsey, A., Sundaram, S., Kiani, M. F., & Pant, K. (2011, March 8). Bifurcations: Focal points of particle adhesion in microvascular networks. Microcirculation, 18, 380-389.

 

Bhattacharjee, H., Nadipuram, A., Kosanke, S., Kiani, M. F., & Moore II, B. M. (2011, January 25). Low volume binary drug therapy for the treatment of hypovolemia. Shock, 35(6), 590-596.

 

2010

Tousi, N., Wang, B., Pant, K., Kiani, M. F., & Prabhakarpandian, B. (2010, July 21). Preferential adhesion of leukocytes near bifurcations is endothelium independent. Microvascular Research, 80, 384-388.

 

Wang, B., Rosano, J. M., Cheheltani, R., Achary, M. P., & Kiani, M. F. (2010). Towards a targeted multi-drug delivery approach to improve therapeutic efficacy in breast cancer. Expert Opinion Drug Delivery, 7(10), 1159-1173.

 

2009

Pattillo, CB; Venegas, B; Donelson, FJ; Del Valle, L; Knight, LC; Chong, PL & Kiani, MF (2009) Radiation-guided targeting of combretastatin encapsulated immunoliposomes to mammary tumors. Pharm. Res., 26(5):1093-1100.

 

Rosano, JM; Tousi, N; Scott, RC; Krynska, B; Rizzo, V; Prabhakarpandian, B; Pant, K; Sundaram, S & Kiani, MF (2009) A physiologically realistic in vitro model of microvascular networks. Biomed Microdevices, 11:1051-1057.

 

Scott, RC; Rosano, JM; Ivanov, Z; Wang, B; Chong, PL; Issekutz, AC; Crabbe, DL; Kiani, MF (2009) Targeting VEGF-encapsulated immunoliposomes to MI heart improves vascularity and cardiac function. FASEB J., 23(10): 3361-3367.

 

2008

Scott, RC; Crabbe, D; Krynska, B; Ansari, R & Kiani, MF (2008) Aiming for the heart: targeted delivery of drugs to diseased cardiac tissue. Expert Opin.Drug Deliv., 5(4):459-470 (invited review).

 

Prabhakarpandian, B; Pant, K; Scott, R; Patillo, CB; Irimia, D; Kiani, MF & Sundaram, S (2008) Synthetic microvascular networks for quantitative analysis of particle adhesion. Biomed. Microdevices, 10(4):585-595.

 

Knappe, D; Otvos, L; De Pascali, F; Cassone, M; Scolaro, L; Abbadessa, G; Carrillo-Infante, C; Kiani, MF; Donelson, F; Hoffmann, R; Surmacz, E (2008) Drug development-targeted screening of leptin agonist glycopeptides. Int. J. Pept. Res. Ther., 14(3): 247-254.

 

Siddiqui, K; Del Valle, L; Morellet, N; Cui, J ; Ghafouri, M ; Mukerjee, R; Urbanska, K; Fan, S; Pattillo, CB; Deshmane, SL; Kiani, MF; Ansari, R; Khalili, K; Roques, BP; Reiss, K; Bouaziz, S; Amini, S; Srinivasan, A & Sawaya, BE (2008) Molecular mimicry in inducing DNA damage between HIV-1 Vpr and the anti-cancer agent, Cisplatin. Oncogene, 27(1):32-43.

 

Wang, B; Scott, RC; Pattillo, CB; Prabhakarpandian, B; Sundaram, S & Kiani, MF (2008) Modeling oxygenation and selective delivery of drug carriers post-myocardial infarction. Adv. Exp. Med. Biol., 614:333-343.

 

2007

Ansari, R; Gaber, MW; Wang, B; Pattillo, CB; Miyamoto, C & Kiani, MF (2007) Anti-TNF-α treatment abrogates radiation induced changes in vascular density and tissue oxygenation. Radiat. Res., 167(1):80–86.

 

Scott, RC; Wang, B; Nallamothu, R; Pattillo, CB; Perez-Liz, G; Issekutz, A; Del Valle, L; Wood, GC & Kiani, MF (2007) Targeted delivery of antibody conjugated liposomal drug carriers to rat myocardial infarction. Biotechnol. Bioeng.,96(4):795-802 (selected as a “Spotlight Article”).

 

Wang, B; Scott, RC; Pattillo, CB; Prabhakarpandian, B; Sundaram, S & Kiani, MF (2007) Microvascular transport model predicts oxygenation changes in the infarcted heart after treatment. Am. J. Physiol., 293(6):H3732-H3739.

 

2006

Nallamothu, R; Wood, GC; Pattillo, CB; Scott, RC; Kiani, MF; Moore, BM & Thoma LA (2006) A tumor vasculature targeted liposome delivery system for combretastatin A4: Design, characterization, and in vitro evaluation. AAPS Pharm. Sci. Tech., 7(2):E32. DOI: 10.1208/pt070232.

 

Nallamothu, R; Wood, GC; Kiani, MF; Moore, BM; Horton, FP & Thoma LA (2006) A targeted liposome delivery system for combretastatin A4: formulation optimization through drug loading and in vitro release studies. PDA J. Pharm. Sci. Technol., 60(3):144-155.

 

Yuan, H.; Gaber, MW; Boyd, K; Wilson, CM; Kiani, MF & Merchant, TE (2006) Effects of fractionated radiation on the brain vasculature in a murine model: Blood-brain barrier permeability, astrocyte proliferation, and ultrastructural changes. Int. J. Radiat. Oncol. Biol. Phys., 66(3):860-866.

 

Kiani, MF (2006) Do I need to “believe” in the theory of evolution to be a good biomedical engineer? BMES Bull., 30(2):7-8.

 

2005

Pattillo, CB; Sari-Sarraf, F; Nallamothu, R; Moore, BM; Wood, GC & Kiani, MF (2005) Targeting of the antivascular drug combretastatin to irradiated tumors results in tumor growth delay. Pharm. Res., 22(7), 1117-1120.

 

Wang, B; Ansari, R; Sun, Y; Postlethwaite, AE; Weber, KT & Kiani, MF (2005) The scar neovasculature after myocardial infarction in rats. Am. J. Physiol., 289(1):H108-H113.

 

Yuan, H.; Goetz, DJ; Gaber, MW; Issekutz, AC; Merchant, TE & Kiani, MF (2005) Radiation-induced up-regulation of adhesion molecules in brain microvasculature and their modulation by dexamethasone. Radiat. Res., 163(5):544-551.

 

2004

Gaber, MW; Yuan, H; Killmar, JT; Naimark, MD; Kiani, MF &Merchant, TE (2004) An intravital microscopy study of radiation-induced changes in permeability and leukocyte-endothelial cell interactions in the microvessels of the rat pia matter and cremaster muscle. Brain Res. Protoc., 13(1):1-10.

 

2003

Sakhalkar, HS; Dalal, MK; Salem, A; Ansari, R; Kiani, MF; Hanes, JK; Shakesheff, M & Goetz, DJ (2003) Leukocyte inspired biodegradable particles that selectively and avidly adhere to inflamed endothelium in vitro and in vivo. Proc. Natl. Acad. Sci. USA, 100(26):15895-15900.

 

Weber, KT; Gerling, IC, Kiani, MF, Guntaka, RV, Sun, Y; Ahokas, RA; Postlethwaite, AE & Warrington, KJ (2003) Aldosteronism in heart failure: a proinflammatory/fibrogenic cardiac phenotype. Search for biomarkers and potential drug targets. Curr. Drug Targets, 4(6):505-516.

 

Gaber, MW; Sabek, OM; Fukatsu, K; Wilcox, HG; Kiani, MF & Merchant, TE (2003) The differences in ICAM-1 and TNF-α expression between high single fractions and fractionated irradiation in mouse brain. Int. J. Radiat. Biol., 79(5):359-366.

 

Yuan, H.; Gaber, MW; McColgan, T; Naimark, MD; Kiani, MF & Merchant, TE (2003) Radiation-induced permeability and leukocyte adhesion in the rat blood-brain barrier: Modulation with anti-ICAM-1 antibodies. Brain Res., 969(1-2):59-69.

 

Kiani, MF; Ansari, R & Gaber, MW (2003) Oxygen delivery in irradiated normal tissue. J. Radiat. Res., 44(1):15-21.

 

Gaber, MW; Naimark, MD & Kiani, MF (2003) Dysfunctional microvascular conducted response in irradiated normal tissue. Adv. Exp. Med. Biol., 510:391-395.

 

2002

Kiani, MF; Yuan, H; Chen, X; Smith, L; Gaber, MW & Goetz, DJ (2002) Targeting microparticles to select tissue via radiation-induced upregulation of endothelial cell adhesion molecules. Pharm. Res., 19(9), 1317-1322.

 

Sun, Y; Kiani, MF; Postlethwaite, AE & Weber, KT (2002) Infarct scar as living tissue. Basic Res. Cardiol., 97:343-347 (invited review).

 

Burch, EE; Shinde Patil, VR; Camphausen, RT; Kiani, MF & Goetz, DJ (2002) The N-terminal peptide of PSGL-1 can mediate adhesion to trauma-activated endothelium via P-selectin in vivo. Blood, 100(2):531-538.

 

2001

Prabhakarpandian, B; Goetz, DJ; Swerlick, RA; Xin, C & Kiani, MF (2001) Expression and functional significance of adhesion molecules on cultured endothelial cells in response to ionizing radiation. Microcirculation, 8:355-364.

 

El-Sayed, M; Kiani, MF; Naimark, MD; Hikal, AH & Ghandehari, H (2001) The extravasation of polyamidoamine dendrimers across the microvascular network endothelium. Pharm. Res., 18:23-28.

 

2000

Nguyen, V; Gaber, MW ; Sontag, MR & Kiani, MF (2000) Late effects of ionizing radiation on the microvascular networks in normal tissue. Radiat. Res., 154(5):531-536.

 

1999

Roth, NM; Sontag, MR & Kiani, MF (1999) Early effects of ionizing radiation on the microvascular networks in normal tissue. Radiat. Res., 151(3):270-277.

 

Roth, NM & Kiani, MF (1999) A “Geographic Information Systems” based technique for the study of microvascular networks. Ann. Biomed. Engr., 27(1):42-47.