Independent Career (undergraduate contributions are underlined)


41. Submitted

40. Submitted

39. Submitted

38. Submitted

37. Submitted

36. Jennings, M.C.; Forman, M.E.; Duggan, S.M.; Minbiole, K.P.C.*; Wuest, W.M.* ” Efflux Pumps May Not Be the Major Drivers of QAC Resistance in Methicillin-Resistant Staphylococcus aureus” ChemBioChem 2017 ASAP

35. Solinski, A.E.; Koval, A.B.; Brzozowski, R.S.; Morrison, K.R.; Carson, C.E.Eshraghi, A.R.; Zhou, G.; Quivey, R.G.; Voelz, V.A.; Buttaro, B.A.; Wuest, W.M.* “Diverted Total Synthesis of Carolacton-Inspired Analogs Yields Three Distinct Phenotypes in Streptococcus mutans Biofilms” J. Am. Chem. Soc. 2017 ASAP DOI: 10.1021/jacs.7b03879

34. Allen, R.A.; Jennings, M.C.; Mitchell, M.A.; Al-Khalifa, S.E.; Wuest, W.M.*; Minbiole, K.P.C.* ” Ester- and Amide-containing MultiQACs: Exploring Multicationic Soft Antimicrobial Agents” Bioorg. Med. Chem. Lett. 2017 27, 2107 DOI: 10.1016/j.bmcl.2017.03.077

33. Brzozowski, R.S.; Wuest, W.M.* “Twelve-Membered Macrolactones: Privileged Scaffolds for the Development of New Therapeutics” Chemical Biology & Drug Design 2017 89, 169 (invited review) DOI: 10.1111/cbdd.12783

32. Al-Khalifa, S.E.; Jennings, M.C.; Wuest, W.M.*; Minbiole, K.P.C.* “The Development of Next Generation Pyridinium-Based multiQAC Antiseptics” ChemMedChem 2017 12, 280 DOI: 10.1002/cmdc.201600546

31. Zubris, D.L.*; Minbiole, K.P.C.*; Wuest, W.M.* “Polymeric Quaternary Ammonium Compounds: Versatile Antimicrobial Materials.” Current Topics in Medicinal Chemistry 2017 17, 305 DOI: 10.2174/1568026616666160829155805


30. Forman, M.E.; Jennings, M.C.; Wuest, W.M.*; Minbiole, K.P.C.* “Building a Better QAC: Branched Tetracationic Antiseptics” ChemMedChem 2016 11, 1401 (Highlighted on the back cover!) DOI: 10.1002/cmdc.201600176

29. Jennings, M.C.; Wuest, W.M.* “Natural Product-Inspired Approaches to Combat Bacteria” Tetrahedron 2016 72, 3547. DOI: 10.1016/j.tet.2016.04.064 (Editorial Preface for Tetrahedron Symposium-in-Print)

28. Minbiole, K.P.C.*; Jennings, M.C.; Ator, L.E.; Black, J.W.; Grenier, M.C.; LaDow, J.E.; Caran, K.L.; Seifert, K.; Wuest, W.M.* “From Antimicrobial Activity to Mechanism of Resistance: The Multifaceted Role of Simple Quaternary Ammonium Compounds in Bacterial Eradication” Tetrahedron 2016 72, 3559. DOI: 10.1016/j.tet.2016.01.014

27. Steele, A.D.; Keohane, C.E.; Knouse, K.W.; Rossiter, S.E.; Williams, S.J.; Wuest, W.M.* “Diverted Total Synthesis of Promysalin Analogs Demonstrates that an Iron-Binding Motif is Responsible for its Narrow-spectrum Antibacterial Activity” J. Am. Chem. Soc. 2016 138, 5833.  DOI: 10.1021/jacs.6b03373

26. Forman, M.E.; Fletcher, M.H.; Jennings, M.C.; Duggan, S.M.; Minbiole, K.P.C.*; Wuest, W.M.* “Structure-Resistance Relationships: Interrogating Antiseptic Resistance in Bacteria with Multicationic Quaternary Ammonium Dyes” ChemMedChem 2016 11, 958. DOI: 10.1002/cmdc.201600095

25. Knouse, K.W.; Wuest, W.M.* “The Enantioselective Synthesis and Biological Evaluation of Chimeric Promysalin Analogs Facilitated by Diverted Total Synthesis” J. Antibiotics 2016 69, 337. DOI: 10.1038/ja.2016.4 (invited paper for Amos B. Smith, III issue)

24. Joyce, M.D.; Jennings, M.C.; Santiago, C.N.; Fletcher, M.H.; Wuest, W.M.*; Minbiole, K.P.C.* “Natural Product-Derived Quaternary Ammonium Compounds with Potent Antimicrobial Activity” J. Antibiotics 2016 69, 344. DOI: 10.1038/ja.2015.107 (invited paper for A.B. Smith, III issue)

23. Koval, A.B.; Wuest, W.M.* “An optimized synthesis of the potent and selective Pak1 inhibitor FRAX-1036” Tetrahedron Lett. 2016 57, 449. DOI: 10.1016/j.tetlet.2015.12.059


22. Keohane, C.E.; Steele, A.D.; Wuest, W.M.* “The rhizosphere microbiome: A playground for natural product chemists” Synlett 2015 26, 2739. DOI: 10.1055/s-0035-1560711 (invited Synpact Paper)

21. Mitchell, M.A.; Iannetta, A.A.; Jennings, M.C.; Fletcher, M.H.; Wuest, W.M.*; Minbiole, K.P.C.* “Scaffold-hopping of Multicationic Amphiphiles Yields Three New Classes of Antimicrobials” ChemBioChem 2015 16, 2299. DOI: 10.1002/cbic.201500381  (highlighted as a Very Important Paper)

20. Steele, A.D.; Knouse, K.W.; Keohane, C.E.; Wuest, W.M.* “Total Synthesis and Biological Evaluation of (-)-Promysalin” J. Am. Chem. Soc. 2015 137, 7314DOI: 10.1021/jacs.5b04767

19. Jennings, M.C.; Minbiole, K.P.C.; Wuest, W.M.* “Quaternary Ammonium Compounds: An Antimicrobial Mainstay and Platform for Innovation to Address Bacterial Resistance” ACS Infectious Diseases, 2015 1, 288. DOI: 10.1021/acsinfecdis.5b00047

18. Jennings, M.C.; Buttaro, B.A.; Minbiole, K.P.C.; Wuest, W.M.* “Bioorganic Investigation of Multicationic Antimicrobials to Combat QAC-Resistant Staphylococcus aureus” ACS Infectious Diseases, 2015 1, 304DOI: 10.1021/acsinfecdis.5b00032

17. Wakefield, A.E.; Wuest, W.M.; Voelz, V.A.* “Molecular Simulation of Conformational Pre-organization in Cyclic RGD Peptides.” J. Chem. Inf. Model2015 55, 806. DOI: 10.1021/ci500768u


16. Paniak, T.J.; Jennings, M.C.; Shanahan, P.C.; Joyce, M.D.; Santiago, C.N.; Wuest, W.M.*; Minbiole, K.P.C.* “The antimicrobial activity of mono-, bis-, tris-, and tetracationic amphiphiles derived from simple polyamine platforms.” Bioorg. Med. Chem. Lett. 2014 24, 5824DOI: 10.1016/j.bmcl.2014.10.018

15. Kinzie, C.R.; Steele, A.D.; Pasciolla, S.M.; Wuest, W.M.* “Synthesis of cyclic dimeric methyl morpholinoside – a common synthetic precursor to cyclic dinucleotide analogs.” Tetrahedron Lett. 2014 55, 4966. DOI: 10.1016/j.tetlet.2014.07.038

14. Ator, L.C.; Jennings, M.C.; McGettigan, A.R.; Paul, J.J.; Wuest, W.M.*; Minbiole, K.P.C.* “Beyond paraquats: Dialkyl 3,3′- and 3,4′-bipyridinium amphiphiles as antibacterial agents” Bioorg. Med. Chem. Lett.  2014  24, 3706.  DOI: 10.1016/j.bmcl.2014.07.024 

13. Jennings, M.C.; Ator, L.C.; Paniak, T.J.; Minbiole, K.P.C.*; Wuest, W.M.* “Biofilm Eradicating Properties of Quaternary Ammonium Amphiphiles: Simple Mimics of Antimicrobial Peptides” ChemBioChem 2014 15, 2211. DOI: 10.1002/cbic.201402254

12. Fletcher, M.H.; Jennings, M.C.; Wuest, W.M.* “Draining the moat: Disrupting bacterial biofilms with natural products” Tetrahedron 2014 70, 6373. DOI: 10.1016/j.tet.2014.06.055 (invited review)

11. Wuest, W.M.*; Wuest, L.M* “Using Technology to Create an Active, Collaborative Learning Environment: Even in Organic Chemistry!” Proceedings of the 2014 Lilly Conference on College and University Teaching and Learning 2014 44.

10. Razavi, A. M.; Wuest, W.M.*; Voelz, V.A.* “Computational screening and selection of cyclic peptide hairpin mimetics by molecular simulation and kinetic network models.” J. Chem. Inf. Model. 2014 54, 1425.  DOI: 10.1021/ci500102y

9. Hallside, M.S.; Brzozowski, R.S.; Wuest, W.M.*; Phillips, A.J.* “A Concise Synthesis of Carolacton” Org. Lett. 2014 16, 1148. DOI: 10.1021/ol500004k (Highlighted by Org. Lett. as a top 10 accessed article from Jan-Jun 2014)

8. Black, J.W.; Jennings, M.C.; Azarewicz, J.; Grenier, M.C.; Wuest, W.M.*; Minbiole, K.P.C.* “TMEDA-derived biscationic amphiphiles: An economical preparation of potent antibacterial agents” Bioorg. Med. Chem Lett. 2014 24, 99. DOI: 10.1016/j.bmcl.2013.11.070

Prior Publications (2008-2011)

7. Wuest, W.M.; Krahn, D.; Kaiser, M.; Walsh, C.T.*; “Enzymatic Timing and Tailoring of Macrolactomization in Syringolin Biosynthesis.” Org. Lett. 2011 13, 4518. DOI:10.1021/ol2016687

6. Imker, H.J.; Walsh, C.T.*; Wuest, W.M. “SylC Catalyzes Ureido-Bond Formation During Biosynthesis of the Proteasome Inhibitor Syringolin A.” J. Am. Chem. Soc. 2009 131, 18263. DOI: 10.1021/ja909170u

5. Wuest, W.M.; Sattely, E.S.; Walsh, C.T.* “Three Siderophores from One Bacterial Enzymatic Assembly Line.” J. Am. Chem. Soc. 2009 131, 5056. DOI: 10.1021/ja900815w

4. Smith III, A.B.*; Wuest, W.M. “Evolution of Multi-Component Anion Relay Chemistry (ARC): Construction of Architecturally Complex Natural and Unnatural Products.” Chem. Commun. 2008 45, 5883. DOI: 10.1039/B810394A

3. Smith III, A.B.*; Cox, J.M.; Furuichi, N.; Kenesky, C.S.; Zheng, J.; Atasoylu, O.; Wuest, W.M.; “Total Synthesis of (-)-2-epi-peloruside A.” Org. Lett. 2008 10, 5501. DOI: 10.1021/ol8019132

2. Smith III, A.B.*; Kim, W.S.; Wuest, W.M.; “Ortho-TMS Benzaldehyde: an Effective Linchpin for Type II Anion Relay Chemistry (ARC).” Angew. Chem. Int. Ed. 2008 47, 7082. DOI:10.1002/anie.200802301

1. Carney, J.M.; Donoghue, P.J.; Wuest, W.M.; Wiest, O.*; Helquist, P.* “Intramolecular Hydroamination of Aminoalkynes with Silver Phenanthroline Catalysts.” Org. Lett. 2008 10, 3903. DOI: 10.1021/ol801458g