Department of Chemistry
440 Beury Hall
Philadelphia, PA 19122
email: wwuest [at] temple [dot] edu
Bill was born in Centereach, NY in 1981. He received his B.S. magna cum laude in Chemistry/Business from the University of Notre Dame in 2003. As an undergraduate, he investigated intramolecular hydroamination reactions under the tutelage of Professor Paul Helquist. Bill then moved to Philadelphia, PA to begin his graduate studies at the University of Pennsylvania working with Professor Amos B. Smith, III. His graduate work focused on both the total synthesis of peloruside A and the development of Anion Relay Chemistry (ARC) culminating with a Ph.D. in 2008. Bill then traveled to Harvard Medical School as a Ruth Kirschstein-NRSA Postdoctoral Fellow in the laboratory of Professor Christopher T. Walsh, where he investigated unusual enzymatic transformations in the construction of non-ribosomal peptide natural products.
In July of 2011, Bill began his independent career as an Assistant Professor at Temple University and in 2016 was named the Daniel Swern Early Career Professor of Chemistry. His research focuses on the development of chemical tools to better understand bacteria with a specific focus on anti-virulence targets and narrow-spectrum therapeutics. He is also a member of the Molecular Therapeutics Division of Fox Chase Cancer Center and the Scientific Founder of NovaLyse BioSolutions, which seeks to commercialize the QAC technology developed in collaboration with the Minbiole Group at Villanova University. Bill is the recipient of a number of awards including the NIH ESI Maximizing Investigators Research Award (MIRA), NSF CAREER Award, the Young Investigator Award from the Center for Biofilm Engineering at Montana State University, the New Investigator Award from the Charles E. Kaufman Foundation, the Thieme Journal of Chemistry Award, and the Italia-Eire Foundation Distinguished Teacher of the Year Award from the College of Science and Technology at Temple University. Bill is an avid sports fan, with allegiances to the NY Yankees, NY Giants, and his alma mater, the Notre Dame Fighting Irish. Outside the lab he enjoys spending time with his wife, Liesl, and son, Max.