{"id":432,"date":"2022-03-02T11:50:12","date_gmt":"2022-03-02T16:50:12","guid":{"rendered":"https:\/\/sites.temple.edu\/voelzlab\/?p=432"},"modified":"2022-03-02T11:50:12","modified_gmt":"2022-03-02T16:50:12","slug":"hot-off-the-press-a-new-peptide-stapling-method-from-the-wang-lab","status":"publish","type":"post","link":"https:\/\/sites.temple.edu\/voelzlab\/2022\/03\/02\/hot-off-the-press-a-new-peptide-stapling-method-from-the-wang-lab\/","title":{"rendered":"Hot off the press: a new peptide stapling method from the Wang lab"},"content":{"rendered":"\n<p>Congrats to Voelz Lab student Si Zhang for her modeling and simulation contributions to this exciting new methodology developed by the <a rel=\"noreferrer noopener\" href=\"https:\/\/rosswang.weebly.com\/\" data-type=\"URL\" data-id=\"https:\/\/rosswang.weebly.com\/\" target=\"_blank\">Ross Wang Lab<\/a> at Temple.  These new staples use a fluorine thiol-displacement reaction for cyclization, resulting in peptides that not only are more stable their folded conformations, but are also taken up by multiple kinds of cancer cells.   From large-scale folding simulations of various staple designs, Si achieved good agreement with experimental and simulated peptide helicity, suggesting that folding simulations can be a predictive tool for peptide staple design.<\/p>\n\n\n\n<p>You can read all about it in the latest issue of <em>Nature Communications<\/em>:<\/p>\n\n\n\n<p><strong>Unprotected Peptide Macrocyclization and Stapling via A Fluorine-Thiol Displacement Reaction<\/strong>. Md Shafiqul Islam, Samuel Junod, Si Zhang, Zakey Buuh, Yifu Guan, Mi Zhao, Kishan Kaneria, Parmila Kafley, Carson Cohen, Robert Maloney, Zhigang Lyu, Vincent A. Voelz, Weidong Yang, and Rongsheng Wang.  <em>Nature Communications<\/em>\u00a0<strong>13,\u00a0<\/strong>350 (2022). <a rel=\"noreferrer noopener\" href=\"https:\/\/doi.org\/10.1038\/s41467-022-27995-5\" target=\"_blank\">https:\/\/doi.org\/10.1038\/s41467-022-27995-5<\/a> <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Congrats to Voelz Lab student Si Zhang for her modeling and simulation contributions to this exciting new methodology developed by the Ross Wang Lab at Temple. These new staples use a fluorine thiol-displacement reaction for cyclization, resulting in peptides that not only are more stable their folded conformations, but are also taken up by multiple &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/sites.temple.edu\/voelzlab\/2022\/03\/02\/hot-off-the-press-a-new-peptide-stapling-method-from-the-wang-lab\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Hot off the press: a new peptide stapling method from the Wang lab&#8221;<\/span><\/a><\/p>\n","protected":false},"author":1258,"featured_media":0,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-432","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/sites.temple.edu\/voelzlab\/wp-json\/wp\/v2\/posts\/432","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.temple.edu\/voelzlab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.temple.edu\/voelzlab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.temple.edu\/voelzlab\/wp-json\/wp\/v2\/users\/1258"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.temple.edu\/voelzlab\/wp-json\/wp\/v2\/comments?post=432"}],"version-history":[{"count":0,"href":"https:\/\/sites.temple.edu\/voelzlab\/wp-json\/wp\/v2\/posts\/432\/revisions"}],"wp:attachment":[{"href":"https:\/\/sites.temple.edu\/voelzlab\/wp-json\/wp\/v2\/media?parent=432"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.temple.edu\/voelzlab\/wp-json\/wp\/v2\/categories?post=432"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.temple.edu\/voelzlab\/wp-json\/wp\/v2\/tags?post=432"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}