{"id":333,"date":"2021-03-23T17:38:10","date_gmt":"2021-03-23T21:38:10","guid":{"rendered":"https:\/\/sites.temple.edu\/voelzlab\/?p=333"},"modified":"2021-03-23T17:38:11","modified_gmt":"2021-03-23T21:38:11","slug":"congrats-to-matt-on-q-pro-macrocycle-paper","status":"publish","type":"post","link":"https:\/\/sites.temple.edu\/voelzlab\/2021\/03\/23\/congrats-to-matt-on-q-pro-macrocycle-paper\/","title":{"rendered":"Congrats to Matt on Q-Pro macrocycle paper"},"content":{"rendered":"\n<p>Congrats to Matt Hurley and the multi-disciplinary team of Temple researchers from the <a rel=\"noreferrer noopener\" href=\"https:\/\/www.schafmeistergroup.com\/\" target=\"_blank\">Schafmeister<\/a>, <a rel=\"noreferrer noopener\" href=\"https:\/\/www.cst.temple.edu\/~mzdilla\/\" target=\"_blank\">Zdilla<\/a>, and <a rel=\"noreferrer noopener\" href=\"https:\/\/sites.temple.edu\/baxterlab\/richard-baxter\/\" target=\"_blank\">Baxter<\/a> groups on this new manuscript describing <a rel=\"noreferrer noopener\" href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.joc.1c00116\" target=\"_blank\">Metal-Binding Q-Proline Macrocycles<\/a>.   As Matt shows in a companion theory paper (still in review, stay tuned), these highly-functionalizable molecules slowly pre-organize in the presence of cations to an all-<em>trans<\/em> amide conformation.  Interestingly, a solid-state racemic crystal structure obtained by first author JD Northrup and team does <em>NOT <\/em>show all all-trans backbone, underscoring the  need to model solution-state conformational properties.<\/p>\n\n\n\n<p>Metal-Binding Q-Proline Macrocycles<br>Justin D. Northrup<em>, <\/em>Jesse A. Wiener, Matthew F. D. Hurley, Chun-Feng David Hou, Taylor M. Keller, Richard H. G. Baxter, Michael J. Zdilla, Vincent A. Voelz, and Christian E. Schafmeister<br>J. Org. Chem. 2021, 86, 6, 4867\u20134876<br>doi:<a href=\"http:\/\/doi.org\/10.1021\/acs.joc.1c00116\" target=\"_blank\" rel=\"noreferrer noopener\">10.1021\/acs.joc.1c00116<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Congrats to Matt Hurley and the multi-disciplinary team of Temple researchers from the Schafmeister, Zdilla, and Baxter groups on this new manuscript describing Metal-Binding Q-Proline Macrocycles. As Matt shows in a companion theory paper (still in review, stay tuned), these highly-functionalizable molecules slowly pre-organize in the presence of cations to an all-trans amide conformation. Interestingly, &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/sites.temple.edu\/voelzlab\/2021\/03\/23\/congrats-to-matt-on-q-pro-macrocycle-paper\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Congrats to Matt on Q-Pro macrocycle paper&#8221;<\/span><\/a><\/p>\n","protected":false},"author":1258,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-333","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/sites.temple.edu\/voelzlab\/wp-json\/wp\/v2\/posts\/333","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.temple.edu\/voelzlab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.temple.edu\/voelzlab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.temple.edu\/voelzlab\/wp-json\/wp\/v2\/users\/1258"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.temple.edu\/voelzlab\/wp-json\/wp\/v2\/comments?post=333"}],"version-history":[{"count":0,"href":"https:\/\/sites.temple.edu\/voelzlab\/wp-json\/wp\/v2\/posts\/333\/revisions"}],"wp:attachment":[{"href":"https:\/\/sites.temple.edu\/voelzlab\/wp-json\/wp\/v2\/media?parent=333"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.temple.edu\/voelzlab\/wp-json\/wp\/v2\/categories?post=333"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.temple.edu\/voelzlab\/wp-json\/wp\/v2\/tags?post=333"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}