Curli Containing Enteric Biofilms Inside and Out: Matrix Composition, Immune Recognition, and Disease Implications

Sarah Tursi and Cagla Tukel. In press. Microbiology and Molecular Biology Reviews

A Nonpyroptotic IFN-g–Triggered Cell Death Mechanism in Nonphagocytic Cells Promotes Salmonella Clearance In Vivo

Justin P. Ingram, Sarah Tursi, Ting Zhang, Wei Guo, Chaoran Yin, Meghan Wynosky-Dolfi, Joris van der Heijden, Kathy Q. Cai, Masahiro Yamamoto, B. Brett Finlay, Igor E. Brodsky, Sergei I. Grivennikov, Cagla Tukel, and Siddharth Balachandran, PMID: 29654208

The Functional Amyloid Curli Protects Escherichia coli against Complement-Mediated Bactericidal Activity

Biesecker SG, Nicastro LK, Wilson RP, Tükel Ç.Biomolecules. 2018 Jan 24;8(1). pii: E5. doi: 10.3390/biom8010005. PMID:29364839 

Precision editing of the gut microbiota ameliorates colitis

Zhu W, Winter MG, Byndloss MX, Spiga L, Duerkop BA, Hughes ER, Büttner L, de Lima Romão E, Behrendt CL, Lopez CA, Sifuentes-Dominguez L, Huff-Hardy K, Wilson RP, Gillis CC, Tükel Ç, Koh AY, Burstein E, Hooper LV, Bäumler AJ, Winter SE. Nature. 2018 Jan 11;553(7687):208-211. doi: 10.1038/nature25172. Epub 2018 Jan 3. PMID:29323293

Bacterial amyloid curli acts as a carrier for DNA to elicit an autoimmune response via TLR2 and TLR9

Tursi SA, Lee EY, Medeiros NJ, Lee MH, Nicastro LK, Buttaro B, Gallucci S, Wilson RP, Wong GCL, Tükel Ç.PLoS Pathog. 2017 Apr 14;13(4):e1006315. doi: 10.1371/journal.ppat.1006315. eCollection 2017 Apr. PMID: 28410407. PMID:28410407

Biofilm-associated bacterial amyloids dampen inflammation in the gut: oral treatment with curli fibres reduces the severity of hapten-induced colitis in mice

Oppong GO, Rapsinski GJ, Tursi SA, Biesecker SG, Klein-Szanto AJ, Goulian M, McCauley C, Healy C, Wilson RP, Tükel C.NPJ Biofilms Microbiomes. 2015;1. pii: 15019. Epub 2015 Oct 14. PMID:26855788

 Amyloid-DNA Composites of Bacterial Biofilms Stimulate Autoimmunity

Gallo PM, Rapsinski GJ, Wilson RP, Oppong GO, Sriram U, Goulian M, Buttaro B, Caricchio R, Gallucci S, Tükel Ç. Immunity. 2015 Jun 16;42(6):1171-84. doi: 10.1016/j.immuni.2015.06.002. PMID:26084027

Toll-like receptor 2 and NLRP3 cooperate to recognize a functional bacterial amyloid, curli

Rapsinski GJ, Wynosky-Dolfi MA, Oppong GO, Tursi SA, Wilson RP, Brodsky IE, Tükel Ç. Infect Immun. 2015 Feb;83(2):693-701. doi: 10.1128/IAI.02370-14. Epub 2014 Nov 24. PMID:25422268

 Disease to dirt: the biology of microbial amyloids

Hufnagel DA, Tükel C, Chapman MR.PLoS Pathog. 2013;9(11):e1003740. doi: 10.1371/journal.ppat.1003740. Epub 2013 Nov 21. Review. No abstract available. PMID: 24278013

CD14 protein acts as an adaptor molecule for the immune recognition of Salmonella curli fibers

Rapsinski GJ, Newman TN, Oppong GO, van Putten JP, Tükel Ç. J Biol Chem. 2013 May 17;288(20):14178-88. doi: 10.1074/jbc.M112.447060. Epub 2013 Apr 2. PMID: 23548899

Epithelial cells augment barrier function via activation of the Toll-like receptor 2/phosphatidylinositol 3-kinase pathway upon recognition of Salmonella enterica serovar Typhimurium curli fibrils in the gut

Oppong GO, Rapsinski GJ, Newman TN, Nishimori JH, Biesecker SG, Tükel Ç. Infect Immun. 2013 Feb;81(2):478-86. doi: 10.1128/IAI.00453-12. Epub 2012 Dec 3. PMID: 23208603

Microbial amyloids induce interleukin 17A (IL-17A) and IL-22 responses via Toll-like receptor 2 activation in the intestinal mucosa

Nishimori JH, Newman TN, Oppong GO, Rapsinski GJ, Yen JH, Biesecker SG, Wilson RP, Butler BP, Winter MG, Tsolis RM, Ganea D, Tükel Ç.Infect Immun. 2012 Dec;80(12):4398-408. doi: 10.1128/IAI.00911-12. Epub 2012 Oct 1. PMID: 23027540

The Vi capsular polysaccharide prevents complement receptor 3-mediated clearance of Salmonella enterica serotype Typhi

Wilson RP, Winter SE, Spees AM, Winter MG, Nishimori JH, Sanchez JF, Nuccio SP, Crawford RW, Tükel Ç, Bäumler AJ. Infect Immun. 2011 Feb;79(2):830-7. doi: 10.1128/IAI.00961-10. Epub 2010 Nov 22. PMID: 21098104

Toll-like receptors 1 and 2 cooperatively mediate immune responses to curli, a common amyloid from enterobacterial biofilms

Tükel C, Nishimori JH, Wilson RP, Winter MG, Keestra AM, van Putten JP, Bäumler AJ. Cell Microbiol. 2010 Oct;12(10):1495-505. doi: 10.1111/j.1462-5822.2010.01485.x. PMID: 20497180

Life in the inflamed intestine, Salmonella style

Santos RL, Raffatellu M, Bevins CL, Adams LG, Tükel C, Tsolis RM, Bäumler AJ.mTrends Microbiol. 2009 Nov;17(11):498-506. doi: 10.1016/j.tim.2009.08.008. Epub 2009 Oct 12. Review. PMID: 19819699

Responses to amyloids of microbial and host origin are mediated through toll-like receptor 2

Tükel C, Wilson RP, Nishimori JH, Pezeshki M, Chromy BA, Bäumler AJ. Cell Host Microbe. 2009 Jul 23;6(1):45-53. doi: 10.1016/j.chom.2009.05.020. PMID: 19616765

 The capsule-encoding viaB locus reduces intestinal inflammation by a Salmonella pathogenicity island 1-independent mechanism

Haneda T, Winter SE, Butler BP, Wilson RP, Tükel C, Winter MG, Godinez I, Tsolis RM, Bäumler AJ.nInfect Immun. 2009 Jul;77(7):2932-42. doi: 10.1128/IAI.00172-09. Epub 2009 May 18. PMID: 19451244 

RosE represses Std fimbrial expression in Salmonella enterica serotype Typhimurium

Chessa D, Winter MG, Nuccio SP, Tükel C, Bäumler AJ. Mol Microbiol. 2008 May;68(3):573-87. doi: 10.1111/j.1365-2958.2008.06185.x. Epub 2008 Mar 4. PMID: 18331470

The Vi-capsule prevents Toll-like receptor 4 recognition of Salmonella

Wilson RP, Raffatellu M, Chessa D, Winter SE, Tükel C, Bäumler AJ.nCell Microbiol. 2008 Apr;10(4):876-90. Epub 2007 Nov 22. PMID: 18034866

MarT activates expression of the MisL autotransporter protein of Salmonella enterica serotype Typhimurium

Tükel C, Akçelik M, de Jong MF, Simsek O, Tsolis RM, Bäumler AJ. J Bacteriol. 2007 May;189(10):3922-6. Epub 2007 Mar 9. PMID: 17351045

 Identification of adsorption inhibition, restriction/modification and abortive infection type phage resistance systems in Lactococcus lactis strains

Tükel C, Sanlibaba P, Ozden B, Akçelik M. Acta Biol Hung. 2006 Sep;57(3):377-85. PMID: 17048701 

Neutrophil influx during non-typhoidal salmonellosis: who is in the driver’s seat?

Tükel C, Raffatellu M, Chessa D, Wilson RP, Akçelik M, Bäumler AJ. FEMS Immunol Med Microbiol. 2006 Apr;46(3):320-9. Review. PMID: 16553804