{"id":121,"date":"2026-10-04T22:26:15","date_gmt":"2026-10-05T02:26:15","guid":{"rendered":"https:\/\/sites.temple.edu\/therahmanlab\/?page_id=121"},"modified":"2026-10-05T00:14:25","modified_gmt":"2026-10-05T04:14:25","slug":"my-father-attiq-rahman","status":"publish","type":"page","link":"https:\/\/sites.temple.edu\/therahmanlab\/my-father-attiq-rahman\/","title":{"rendered":"My Father, Attiq Rahman"},"content":{"rendered":"
\n

\n FAMILY \u00b7 CHEMISTRY \u00b7 LEGACY<\/strong>\n <\/p>\n

\n My Father, Attiq Rahman
\n <\/h1>\n

\n A chemist, a father, and one of the foundations of The Rahman Lab.<\/strong>\n <\/p>\n

\n \"Attiq
\n Father and son.
\n <\/figcaption><\/figure>\n

\n My father, Attiq Rahman<\/strong>, was a medicinal chemist whose life and work
\n left a lasting influence on me.\n <\/p>\n

\n He built his career in medicinal chemistry through research at
\n GlaxoSmithKline<\/strong>, where his work contributed to the development
\n of new chemical compounds with medicinal applications toward many diseases.\n <\/p>\n

\n For me, however, his legacy goes far beyond any laboratory notebook, patent, or
\n chemical structure. He was my father. My own path through chemistry, research,
\n teaching, and this work I now call The Rahman Lab<\/strong> exists in part
\n because chemistry was something I grew up seeing him live, breathe, and repeat.\n <\/p>\n

\n

\n Family & Childhood
\n <\/h2>\n
\n
\n \"My
\n My mom and I.
\n <\/figcaption><\/figure>\n
\n \"1989
\n My childhood car, a 1989 Toyota Supra MK3, 7M-GE automatic.
\n <\/figcaption><\/figure>\n<\/p><\/div>\n
\n

\n A Life in Chemistry
\n <\/h2>\n

\n My father\u2019s work was rooted in medicinal chemistry; a subject where organic chemistry,
\n biology, and medicine meet. His career reflected the same idea that still drives much
\n of my own work; chemistry matters most when it is connected to something larger than
\n the reaction itself. Many of the compounds he made were designed with the purpose of
\n treating immuno-inflammatory illnesses, such as lupus and cancer. Tragically, my father
\n Attiq was diagnosed with Stage IV Colon Cancer in May 2018. Despite pursuing an
\n aggressive treatment regimen, the cancer had caused substantial damage, and he passed
\n away in July 2018.\n <\/p>\n

\n His influence stayed with me as I studied chemistry during my undergraduate degree.
\n After waning at a few tough points, my interest in chemistry was rekindled by the rare
\n similarly-spirited professors who made learning fun again. As I progressed through
\n academic research and my degree, eventually teaching chemistry at Temple University,
\n I felt strongly to maintain a similar encouraging and open mindset in my own classroom.\n <\/p>\n

\n Today; whether I am teaching students, rebuilding an old Kawasaki, developing a lab,
\n or working through a synthesis, some part of my dad\u2019s story is still there.\n <\/p>\n

\n

\n Selected Publications
\n <\/h2>\n

\n During his career at GlaxoSmithKline, my father contributed to published work spanning
\n synthetic organic chemistry, cysteine protease inhibitors, calcium receptor antagonists,
\n immuno-inflammatory medicinal chemistry, and RIP1 kinase drug discovery.\n <\/p>\n

\n
\n

\n An Efficient Synthesis of 3-Substituted 3H-Pyrimidin-4-ones<\/strong>\n <\/p>\n

\n Co-author: Attiq Rahman<\/strong>\n <\/p>\n

\n Organic Letters<\/em>, 2004, 6<\/strong>(6), 1013\u20131016\n <\/p>\n

\n DOI: 10.1021\/ol049921v<\/a>\n <\/p>\n<\/p><\/div>\n

\n

\n Azepanone-Based Inhibitors of Human Cathepsin L<\/strong>\n <\/p>\n

\n Co-author: Attiq Rahman<\/strong>\n <\/p>\n

\n Journal of Medicinal Chemistry<\/em>, 2005, 48<\/strong>(22), 6870\u20136878\n <\/p>\n

\n DOI: 10.1021\/jm0502079<\/a>\n <\/p>\n<\/p><\/div>\n

\n

\n Antagonists of the Calcium Receptor. 2. Amino Alcohol-Based Parathyroid Hormone Secretagogues<\/strong>\n <\/p>\n

\n Co-author: Attiq Rahman<\/strong>\n <\/p>\n

\n Journal of Medicinal Chemistry<\/em>, 2009, 52<\/strong>(21), 6599\u20136605\n <\/p>\n

\n DOI: 10.1021\/jm900563e<\/a>\n <\/p>\n<\/p><\/div>\n

\n

\n Synthesis of Tetrasubstituted Pyrazines and Pyrazine N-Oxides<\/strong>\n <\/p>\n

\n Co-author: Attiq Rahman<\/strong>\n <\/p>\n

\n Tetrahedron Letters<\/em>, 2010, 51<\/strong>, 974\u2013976\n <\/p>\n

\n DOI: 10.1016\/j.tetlet.2009.12.053<\/a>\n <\/p>\n<\/p><\/div>\n

\n

\n Azepanone-Based Inhibitors of Human Cathepsin S: Optimization of Selectivity via the P2 Substituent<\/strong>\n <\/p>\n

\n Co-author: Attiq Rahman<\/strong>\n <\/p>\n

\n Bioorganic & Medicinal Chemistry Letters<\/em>, 2011, 21<\/strong>, 4409\u20134415\n <\/p>\n

\n DOI: 10.1016\/j.bmcl.2011.06.045<\/a>\n <\/p>\n<\/p><\/div>\n

\n

\n Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases<\/strong>\n <\/p>\n

\n Co-author: Attiq Rahman<\/strong>\n <\/p>\n

\n Journal of Medicinal Chemistry<\/em>, 2017, 60<\/strong>, 1247\u20131261\n <\/p>\n

\n DOI: 10.1021\/acs.jmedchem.6b01751<\/a>\n <\/p>\n<\/p><\/div>\n<\/p><\/div>\n

\n

\n Patents
\n <\/h2>\n

\n His work also continued into patented medicinal chemistry involving cyclic GMP-AMP
\n synthase, or cGAS, a target involved in immune signaling and inflammatory disease.\n <\/p>\n

\n

\n Triazole-substituted imidazo[1,2-a]pyrimidines as cGAS inhibitors<\/strong>\n <\/p>\n

\n International patent publication\n <\/p>\n

\n Patent No.: WO 2024\/083773 A1<\/a>\n <\/p>\n

\n Published: April 25, 2024\n <\/p>\n<\/p><\/div>\n

\n

\n Triazole-substituted imidazo[1,2-a]pyrimidines as cGAS inhibitors<\/strong>\n <\/p>\n

\n United States patent\n <\/p>\n

\n Patent No.: US 12,247,033 B2<\/a>\n <\/p>\n

\n Granted: March 11, 2025\n <\/p>\n<\/p><\/div>\n

\n

\n Remembered at GlaxoSmithKline
\n <\/h2>\n

\n After reading his obituary from GSK, I learned more about the breadth of the work my
\n father had carried out during his career there. GSK shared the following remembrance:\n <\/p>\n

\n

\n Attiq was a medicinal chemist with nearly 20 years of experience. He joined GSK in
\n 1998 as a co-op student and had impressed management sufficiently to secure a fulltime
\n offer. Over the next 20 years, he contributed to a number of programs including CatK,
\n CaSR, TRPV4, RIP2, RIP1 and STING. During the last few years, Attiq was involved in
\n the cGAS program and was a key contributor to the current class of lead molecules.\n <\/p>\n

\n Attiq will be dearly missed by his friends and colleagues across the organization.
\n Those who knew him well said how much they will miss his positive outlook on life,
\n warm smile and kind and friendly disposition.\n <\/p>\n<\/blockquote>\n

\n \"GSK
\n At my father’s memorial at GlaxoSmithKline.
\n <\/figcaption><\/figure>\n
\n

\n The Rahman Lab is not only about my current chemistry research. It is also about who caused that initial spark of curiosity, decades ago.\n <\/p>\n<\/blockquote>\n

\n His Legacy
\n <\/h2>\n

\n My father passed down more than an interest in science. He passed down an example of
\n intellectual curiosity, technical skill, and the belief that difficult problems are
\n worth working through.\n <\/p>\n

\n His influence continues in the way I approach chemistry, education, research, and
\n problem solving. The work may be different now, but his mindset remains familiar;
\n look carefully around you, focus and try to understand the puzzle, study; and keep
\n working until it makes sense.\n <\/p>\n

\n This page is here to preserve a small part of that story, not simply as the story of
\n a scientist, but as the story of my father, Attiq Rahman<\/strong>.\n <\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

FAMILY \u00b7 CHEMISTRY \u00b7 LEGACY My Father, Attiq Rahman A chemist, a father, and one of the foundations of The Rahman Lab. Father and son.…<\/p>\n

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