The Sillivan Lab is part of the Center for Substance Abuse Research (CSAR) at Temple University Lewis Katz School of Medicine.  Our lab studies molecular mechanisms that sustain continued drug seeking after abstinence in rodent models of drug self-administration. We utilize a combination of both molecular biology and behavioral neuroscience to understand mechanisms within the cell that drive maladaptive behaviors.  Our long-term goal is to improve the scope of druggable targets available for the development of pharmacotherapies to treat substance use disorder (SUD), and specifically, opioid dependence.