Recent Publications

Journal Articles


S Kulyk, BB Khatri, SM Sieburth, “Enyne [4+4] Cycloaddition/Oxidation:  Ring Contraction via Cyclopropanones and Their Anionic Ring-Opening Reactions” Angewandte Chemie International Edition. 2016 Link
PB Finn, BP Derstine, SM Sieburth, “Carbocyclic Amino-Ketones by Bredt’s Rule-Arrested Kulinkovich-de Meijere Reaction.” Angewandte Chemie International Edition. 2016, 55, 2536  Link


BB Khatri, SM Sieburth, “Enyne-2-pyrone [4 + 4]-Photocycloaddition: Sesquiterpene Synthesis and a Low-Temperature Cope Rearrangement.” Organic Letters. 2015, 17, 4360. Link
BB Khatri, D Vrubliauskas, SM Sieburth, “Photo-[4+4]-cycloaddition (para) of meta-substituted benzenes with 2-pyridones.” Tetrahedron Letters. 2015, 56, 4520. Link
PB Finn, S Kulyk, SM Sieburth, “Formation and isomerization of polyclic 1,5-enynes.” Tetrahedron Letters. 2015, 57, 3567. Link


BB Khatri, S Kulyk, SM Sieburth, “Enyne [4+4] photocycloaddition with polycyclic aromatics.” Organic Chemistry Frontiers. 2014, 1, 961-964. Link
S Kulyk, BB Khatri, SM Sieburth, “Stabilization, Isomerization and Rearrangement of Enyne [4+4]-cycloadducts.” Organic Letters. 2014, 16, 4138-4141. Link


Y Bo, PB Finn, BB Khatri, SM Sieburth, “Alpha-amino silanes via metalated imines as an approach to the synthesis of silanediol protease inhibitors.” Tetrahedron. 2013, 69, 7779-7784. Link


S Singh, SM Sieburth, “Serine Protease Inhibition by a Silanediol Peptidomimetic.” Organic Letters. 2012, 14, 4422-4425. Link
JK Kim, SM Sieburth, “Synthesis and Properties of a Sterically Unencumbered delta-Silanediol Amino Acid.” Journal of Organic Chemistry. 2012, 77, 2901-2906. Link
L Chen, Y Lei, AG Shilabin, JD Delaney, GR Baran, SM Sieburth, “beta-Peptide coatings by surface-initiated polymerization.” Chemical Communications. 2012, 48, 9604-9606. Link


S Kulyk, WG Dougherty, WS Kassel, MJ Zdilla, SM Sieburth, “Intramolecular Pyridone/Enyne Photocycloaddition: Partitioning of the [4+4] and [2+2] Pathways.” Organic Letters. 2011, 13, 2180-2183. Link
YJ Bo, S Singh, HQ Duong, C Cao, SM Sieburth, “Efficient, Enantioselective Assembly of Silanediol Protease Inhibitors.” Organic Letters. 2011, 13, 1787-1789. Link


PL Chen, PJ Carroll, SM Sieburth, “Tetraquinanes via [4+4] Photocycloaddition/Transannular Ring Closure.” Organic Letters. 2010, 12, 4510-4512. Link
S Kulyk, WG Dougherty, WS Kassel, SM Sieburth, “Enyne [4+4] Photocycloaddition: Bridged 1,2,5-Cyclooctatrienes.” Organic Letters. 2010, 12, 3296-3299. Link


P Chen, PJ Carroll, SM Sieburth, “Bipiperidines via Sequential [4+4]-[3,3]-Retro-Mannich Reactions.” Organic Letters. 2009, 11, 4540-4543. Link
S Sen, S Singh, SM Sieburth, “A Practical, Two-Step Synthesis of 2-substituted 1,3-Butadienes.” Journal of Organic Chemistry. 2009, 74, 2884-2886. Link


S Sen, M Purushotham, YM Qi, SM Sieburth, “Efficient asymmetric synthesis of silanediol precursors from 1,5-dihydrosiloles.” Organic Letters. 2007, 9, 4963-4965. Link
PL Chen, PJ Carroll, SM Sieburth, “Intramolecular reactivity of trans [4+4] Photodimers of 2-Pyridones.” Synthesis-Stuttgart. 2007, 15, 2351-2359. Link


PL Chen, YP Chen, PJ Carroll, SM Sieburth, “Novel Reaction Pathways for 2-pyridone [4+4] Photoadducts.” Organic Letters. 2006, 8, 3367-3370. Link
CA Chen, SM Sieburth, “Silanediol Protease Inhibitors: From Conception to Validation.” European Journal of Organic Chemistry. 2006, 2, 311-322. Link



     Current – 2010          2009 – 2000           1999 – 1991           FMC & Wender Lab


Books & Chapters

SM Sieburth, “Bioactive Amino Acids, Peptides and Peptidomimetics Containing Silicon.” In Bio-Inspired Silicon-Based Materials,  PM Zelisko, Ed., Advances in Silicon Science 5, J Matisons, Ed., Springer: Netherlands, 2014, pp 103-123. Link
SM Sieburth, “Photocycloaddition of Alkenes (Dienes) to Dienes ([4+2]/[4+4]).” In Synthetic Organic Photochemistry,  J Mattay, AG Griesbeck, Eds., Marcel Dekker: New York, NY, 2004, pp 239-268. Link
SM Sieburth, “Photochemical Reactivity of Pyridones.” In CRC Handbook of Organic Photochemistry and Photobiology,  W Horspool, F Lenci, Eds., CRC Press: Boca Raton, FL, 2004, pp 103-118. Link
SM Sieburth, “The Inter- and Intramolecular [4+4] Photocycloaddition of 2-Pyridones and Its Application to Natural Product Synthesis.” In Advances in Cycloaddition,  M Harmata, Ed., JAI: Greenwich, CT, 1999, pp 85-118. Link