{"id":10,"date":"2017-11-29T14:30:17","date_gmt":"2017-11-29T19:30:17","guid":{"rendered":"https:\/\/sites.temple.edu\/rothberg\/?page_id=10"},"modified":"2022-03-30T07:37:25","modified_gmt":"2022-03-30T11:37:25","slug":"publications","status":"publish","type":"page","link":"https:\/\/sites.temple.edu\/rothberg\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

Rothberg Laboratory publications, from research at the University of Texas Medical School at San Antonio (2002-2008) and Temple University School of Medicine (2008-present). A complete list of Brad Rothberg’s publications can be found here: https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=rothberg+bs<\/a><\/p>\n

1. Rothberg BS.<\/u><\/strong> (2004) Allosteric modulation of ion channels: the case of maxi-K. Science\u2019s STKE <\/strong>(now called<\/em> Science Signaling<\/strong>) 2004:pe16. http:\/\/stke.sciencemag.org\/content\/2004\/227\/pe16.long<\/a><\/p>\n

2. Wang B, Rothberg BS<\/u><\/strong>, Brenner R. (2006) Mechanism of \u03b24 subunit modulation of BK channels. Journal of General Physiology<\/strong> 127:449-465. http:\/\/jgp.rupress.org\/content\/127\/4\/449.long<\/a><\/p>\n

3. Parfenova LV, Crane BM, Rothberg BS.<\/u><\/strong> (2006) Modulation of MthK potassium channel activity at the intracellular entrance to the pore. Journal of Biological Chemistry<\/strong>, 281:21131\u201121138. http:\/\/www.jbc.org\/content\/281\/30\/21131.long<\/a><\/p>\n

4. Parfenova LV, Rothberg BS.<\/u><\/strong> (2006) Genetic screening for functionality of bacterial potassium channel mutants using K+ uptake-deficient Escherichia coli. Methods in Molecular Biology<\/strong> 337:157\u2011165. https:\/\/link.springer.com\/protocol\/10.1385%2F1-59745-095-2%3A157<\/a><\/p>\n

5. Koval OM, Fan Y, Rothberg BS.<\/u><\/strong> (2007) A role for the S0 transmembrane segment in voltage-dependent gating of BK channels. Journal of General Physiology<\/strong>, 129:209-220. http:\/\/jgp.rupress.org\/content\/129\/3\/209.long<\/a><\/p>\n

6. Parfenova LV, Abarca-Heidemann K, Crane BM, Rothberg BS.<\/u><\/strong> (2007) Molecular architecture and divalent cation activation of TvoK, a prokaryotic potassium channel. Journal of Biological Chemistry<\/strong>, 282:24302-24309. http:\/\/www.jbc.org\/content\/282\/33\/24302.long<\/a><\/p>\n

7. Rothberg BS.<\/u><\/strong> (2008) Return of the electric binding site. Journal of General Physiology<\/strong>. 132:487-489. http:\/\/jgp.rupress.org\/content\/132\/5\/487.long<\/a><\/p>\n

8. Wang B, Rothberg BS<\/u><\/strong>, Brenner R. (2009) Mechanism of increased BK channel activation from a channel mutation that causes epilepsy. Journal of General Physiology<\/strong> 133:283-294. http:\/\/jgp.rupress.org\/content\/133\/3\/283.long<\/a><\/p>\n

9. Semenova NP, Abarca-Heidemann K, Loranc E, Rothberg, BS.<\/u><\/strong> (2009) Bimane fluorescence scanning suggests secondary structure near the S3-S4 linker of BK channels. Journal of Biological Chemistry<\/strong> 284:10684-10693. http:\/\/www.jbc.org\/content\/284\/16\/10684.long<\/a><\/p>\n

10. Pau VP, Abarca-Heidemann K, Rothberg BS.<\/u> <\/strong>(2010) Allosteric mechanism of Ca2+<\/sup>-activation and H+<\/sup>-inhibited gating of the MthK K+<\/sup> Journal of General Physiology<\/strong> 135:509-526. http:\/\/jgp.rupress.org\/content\/135\/5\/509<\/a><\/p>\n

11. Thomson AS, Rothberg BS.<\/u> <\/strong>(2010) Voltage-dependent inactivation gating at the selectivity filter of the MthK K+<\/sup> Journal of General Physiology<\/strong> 136:569-579. http:\/\/jgp.rupress.org\/content\/136\/5\/569.long<\/a><\/p>\n

12. Pau VP, Smith FJ, Taylor AB, Parfenova LV, Samakai E, Callaghan MM, Abarca\u2011Heidemann K, Hart PJ, Rothberg BS.<\/u> <\/strong>(2011) Structure and function of multiple Ca2+<\/sup>-binding sites in a K+<\/sup> channel regulator of K+<\/sup> conductance (RCK) domain. Proceedings of the National Academy of Sciences USA <\/strong>108:17684-17689. http:\/\/www.pnas.org\/content\/108\/43\/17684.long<\/a><\/p>\n

13. Mallilankaraman K, Doonan P, C\u00e1rdenas C, Chandramoorthy HC, M\u00fcller M, Miller R, Hoffman NE, Gandhirajan RK, Molg\u00f3 J, Birnbaum MJ, Rothberg BS<\/u><\/strong>, Mak DO, Foskett JK, Madesh M. (2012) MICU1 Is an Essential Gatekeeper for MCU-Mediated Mitochondrial Ca(2+) Uptake that Regulates Cell Survival. Cell<\/strong> 151:630-644. https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0092867412012251?via%3Dihub<\/a><\/p>\n

14. Smith FJ, Pau VP, Cingolani G, Rothberg BS<\/u><\/strong>. (2012) Crystal Structure of a Ba(2+)-Bound Gating Ring Reveals Elementary Steps in RCK Domain Activation. Structure<\/strong> 20:2038\u20112047. https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0969212612003486?via%3Dihub<\/a><\/p>\n

15. Soboloff J, Rothberg BS<\/u><\/strong>, Madesh M, Gill DL. (2012) STIM proteins: dynamic calcium signal transducers. Nature Reviews Molecular Cell Biol<\/strong>ogy<\/strong> 13:549-65. https:\/\/www.nature.com\/articles\/nrm3414<\/a><\/p>\n

16. Rothberg BS<\/u><\/strong>. (2012) The BK channel: a vital link between cellular calcium and electrical signaling. Protein & Cell<\/strong> 3:883-892. https:\/\/link.springer.com\/article\/10.1007%2Fs13238-012-2076-8<\/a><\/p>\n

17. Rothberg BS<\/u><\/strong>, Wang Y, Gill DL. (2012) Orai channel pore properties and gating by STIM: implications from the Orai crystal structure. Science Signaling<\/strong> 6:pe9. http:\/\/stke.sciencemag.org\/content\/6\/267\/pe9.full<\/a><\/p>\n

18. Smith FJ, Rothberg BS<\/u><\/strong>. (2013) Analysis of Ca2+<\/sup>-binding sites in the MthK RCK domain by X\u2011ray crystallography. Methods in Molecular Biology<\/strong> 998:277-287. https:\/\/link.springer.com\/protocol\/10.1007%2F978-1-62703-351-0_22<\/a><\/p>\n

19. Smith FJ, Pau VP, Cingolani G, Rothberg BS<\/u>.<\/strong> (2013) Structural basis of allosteric interactions among Ca2+<\/sup> binding sites in a K+<\/sup> channel RCK domain. Nature Communications<\/strong> 4:2621 doi: 10.1038\/ncomms3621. https:\/\/www.nature.com\/articles\/ncomms3621<\/a><\/p>\n

20. Abarca-Heidemann K, Duchardt-Ferner E, Woehnert J, Rothberg BS<\/u><\/strong>. (2013) Isotope labeling strategies for analysis of an ion channel cytoplasmic domain by NMR spectroscopy. Methods in Molecular Biology<\/strong> 998:289-300. https:\/\/link.springer.com\/protocol\/10.1007%2F978-1-62703-351-0_23<\/a><\/p>\n

21. Wang X, Wang Y, Zhou Y, Hendron E, Mancarella S, Andrake MD, Rothberg BS<\/u><\/strong>, Soboloff J, Gill DL. (2014) Distinct Orai-coupling domains in STIM1 and STIM2 define the Orai\u2011activating site. Nature Communications<\/strong> 5:3183 doi: 10.1038\/ncomms4183. https:\/\/www.nature.com\/articles\/ncomms4183<\/a><\/p>\n

22. Thomson AS, Heer FT, Smith FJ, Hendron E, Bern\u00e8che S, Rothberg BS<\/u>.<\/strong> (2014) Initial steps of inactivation at the K+<\/sup> channel selectivity filter. Proceedings of the National Academy of Sciences USA<\/strong> 111:E1713-E1722. doi: 10.1073\/pnas.1317573111. http:\/\/www.pnas.org\/content\/111\/17\/E1713.long<\/a><\/p>\n

23. Hooper R, Rothberg BS<\/u><\/strong>, Soboloff J. (2014) Neuronal STIMulation at rest. Science Signaling<\/strong> 7:pe18. http:\/\/stke.sciencemag.org\/content\/7\/335\/pe18.full<\/a><\/p>\n

24. McManus OB, Rothberg BS.<\/u><\/strong> (2014) An old probe sheds new light on BK channel pore structure. Journal of General Physiology<\/strong>. 144:499-501. doi: 1085\/jgp.201411306 http:\/\/jgp.rupress.org\/content\/144\/6\/499<\/a><\/p>\n

25. Zhou Y, Wang X, Wang X, Loktionova NA, Cai X, Nwokonko RM, Vrana E, Wang Y, Rothberg BS<\/u><\/strong>, Gill DL. (2015) STIM1 dimers undergo unimolecular coupling to activate Orai1 channels. Nature Communications<\/strong> 6:8395. doi: 10.1038\/ncomms9395. https:\/\/www.nature.com\/articles\/ncomms9395<\/a><\/p>\n

26. Hooper R, Rothberg BS<\/u><\/strong>, Soboloff J. (2016) Sterol hindrance of Orai activation. Science Signaling<\/strong> 9:fs4. http:\/\/stke.sciencemag.org\/content\/9\/418\/fs4.full<\/a><\/p>\n

27. Zhou Y, Cai X, Loktionova NA, Wang X, Nwokonko RM, Wang X, Wang Y, Rothberg BS<\/u><\/strong>, Trebak M, Gill DL. (2016) The STIM1 binding site nexus remotely controls Orai1 channel gating. Nature Communications<\/strong> 7:13725. doi: 10.1038\/ncomms13725. https:\/\/www.nature.com\/articles\/ncomms13725<\/a><\/p>\n

28. Giraldez T, Rothberg BS.<\/u><\/strong> (2017) Understanding the conformational motions of RCK gating rings. Journal of General Physiology<\/strong> 149:431-441. pii: jgp.201611726. doi: 10.1085\/jgp.201611726. http:\/\/jgp.rupress.org\/content\/149\/4\/431.long<\/a><\/p>\n

29. Rothberg BS<\/u><\/strong>. (2017) A Slick, Slack pathway through the pore. Journal of Physiology<\/strong> 595:2337\u20112338. doi:10.1113\/JP273497. https:\/\/physoc.onlinelibrary.wiley.com\/doi\/full\/10.1113\/JP273497<\/a><\/p>\n

30. Howard RJ, Carnevale V, Delemotte L, Hellmich UA, Rothberg BS.<\/u><\/strong> (2018) Permeating disciplines: overcoming barriers between molecular simulations and classical structure-function approaches in biological ion transport. Biochimica et Biophysica Acta <\/strong>1860:927-942. pii: S0005-2736(17)30405-4. doi: 10.1016\/j.bbamem.2017.12.013. https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0005273617304054?via%3Dihub<\/a><\/p>\n

31. Li Q, Li Y, Wei H, Pan H-M, Vouga AG, Rothberg BS<\/u><\/strong>, Wu Y, Yan J. (2018) Molecular determinants of Ca2+<\/sup> sensitivity at the intersubunit interface of the BK channel gating ring. Scientific Reports<\/strong> 8:509. doi: 10.1038\/s41598-017-19029-8. https:\/\/www.nature.com\/articles\/s41598-017-19029-8<\/a><\/p>\n

32. Rothberg BS<\/u><\/strong>. (2018) Charge of the Proton Channel. Biophysical Journal<\/strong> 114:2759-2761. doi:\u00a0 10.1016\/j.bpj.2018.05.008.\u00a0https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0006349518305848?via%3Dihub<\/a><\/p>\n

33. Kopec W, Rothberg BS<\/u><\/strong>, de Groot BL.\u00a0(2019) Molecular mechanism of a potassium channel gating through activation gate-selectivity filter coupling. Nature Communications<\/strong> 10:5366. doi: 10.1038\/s41467-019-13227-w. https:\/\/www.nature.com\/articles\/s41467-019-13227-w<\/a><\/p>\n

34. Rockman ME, Vouga AG, Rothberg BS<\/u><\/strong>. (2020) Molecular mechanism of BK channel activation by the smooth muscle relaxant NS11021. Journal of General Physiology<\/strong> 152:e201912506. doi: 10.1085\/jgp.201912506. https:\/\/rupress.org\/jgp\/article\/doi\/10.1085\/jgp.201912506<\/a><\/p>\n

35. Suma A, Granata D, Thomson AS, Carnevale V, Rothberg BS<\/u><\/strong>. (2020) Polyamine blockade and binding energetics in the MthK potassium channel. Journal of General Physiology<\/strong> 152:e201912527. doi: 10.1085\/jgp.201912527. https:\/\/rupress.org\/jgp\/article-lookup\/doi\/10.1085\/jgp.201912527<\/a><\/p>\n

36. Maduke MC, Rothberg BS<\/u><\/strong>. (2020) An international gathering of physiologists in Valparaiso, Chile. Journal of General Physiology<\/strong> 152:e202012626. doi: 10.1085\/jgp.202012626. https:\/\/rupress.org\/jgp\/article-lookup\/doi\/10.1085\/jgp.202012626<\/a><\/p>\n

37. Brauchi SE, Rothberg BS<\/u><\/strong>. (2020) Gating and calcium-sensing mechanisms of TRPA1 channels revealed. Cell Calcium<\/strong> 91:102278. https:\/\/doi.org\/10.1016\/j.ceca.2020.102278<\/a><\/p>\n

38. Vouga AG, Rockman ME, Yan J, Jacobson MA, Rothberg BS<\/u><\/strong>. (2021) State-dependent inhibition of BK channels by the opioid agonist loperamide. Journal of General Physiology\u00a0<\/strong>153:e202012834. https:\/\/doi.org\/10.1085\/jgp.202012834<\/a>.<\/p>\n

\n
39. Kopec W, Thomson AS, de Groot BL, Rothberg BS<\/u><\/strong>. (2022) Driving Forces underlying Selectivity Filter Gating in the MthK Potassium Channel. bioRxiv <\/span>2022.03.29.486236; <\/span>https:\/\/doi.org\/10.1101\/2022.03.29.486236<\/span><\/a>.<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Rothberg Laboratory publications, from research at the University of Texas Medical School at San Antonio (2002-2008) and Temple University School of Medicine (2008-present). A complete list of Brad Rothberg’s publications can be found here: https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=rothberg+bs 1. Rothberg BS. (2004) Allosteric modulation of ion channels: the case of maxi-K. Science\u2019s STKE (now called Science Signaling) 2004:pe16. […]<\/p>\n","protected":false},"author":14250,"featured_media":0,"parent":0,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"template-page-fullwidth.php","meta":{"footnotes":""},"class_list":["post-10","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sites.temple.edu\/rothberg\/wp-json\/wp\/v2\/pages\/10","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.temple.edu\/rothberg\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.temple.edu\/rothberg\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.temple.edu\/rothberg\/wp-json\/wp\/v2\/users\/14250"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.temple.edu\/rothberg\/wp-json\/wp\/v2\/comments?post=10"}],"version-history":[{"count":0,"href":"https:\/\/sites.temple.edu\/rothberg\/wp-json\/wp\/v2\/pages\/10\/revisions"}],"wp:attachment":[{"href":"https:\/\/sites.temple.edu\/rothberg\/wp-json\/wp\/v2\/media?parent=10"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}