{"id":4,"date":"2026-10-01T12:11:10","date_gmt":"2026-10-01T16:11:10","guid":{"rendered":"https:\/\/sites.temple.edu\/danliu\/?page_id=4"},"modified":"2026-10-01T14:00:51","modified_gmt":"2026-10-01T18:00:51","slug":"dan-liu-bioengineering-temple-university","status":"publish","type":"page","link":"https:\/\/sites.temple.edu\/danliu\/","title":{"rendered":"Home"},"content":{"rendered":"\n

Dan Liu<\/h1>\n\n\n\n

I build the devices behind the science.<\/p>\n\n\n\n

Presidential Fellow, Temple University \u00b7 PhD Candidate in Bioengineering<\/strong><\/p>\n\n\n\n

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ABOUT<\/h2>\n\n\n\n
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\"Dan<\/figure>\n<\/div>\n\n\n\n
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I build microphysiological systems \u2014 organ-on-chip platforms \u2014 that model human vascular biology for drug discovery.<\/p>\n\n\n\n

Before returning for the PhD, I spent 10+ years in pharma \u2014 process engineering, product management, CMC business development, and drug\/device combination products. The full industry record lives on my personal site: danliu.bio<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n

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RESEARCH<\/h2>\n\n\n\n
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Sepsis is the proving ground. The platform is the point.<\/p>\n<\/blockquote>\n\n\n\n

My doctoral work centers on a biomimetic microvascular platform for studying neutrophil\u2013endothelial interactions in sepsis, paired with proteomics-driven network modeling and AI-enabled repurposing of FDA-approved therapeutics.<\/p>\n\n\n\n

The platform is a general toolkit for new approach methodologies (NAMs) in drug development: organ-on-chip, proteomics, and computational modeling.<\/p>\n\n\n\n

\"Graphical
Graphical abstract, Lab on a Chip 2026: a biomimetic microvascular platform for studying neutrophil\u2013endothelial interactions in sepsis.<\/figcaption><\/figure>\n\n\n\n
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FABRICATION & TRANSLATION<\/h2>\n\n\n\n

I also work hands-on in microfluidic chip fabrication alongside Shuai Yu, a PhD student in Dr. Ren Fei’s research group, through a collaboration between Dr. Ren’s group and Dr. Kiani’s group. This is the manufacturing craft behind the science. Longer term, I am exploring translating this fabrication capability into a university spinoff, so the devices and know-how built here can reach the researchers and teams who need them.<\/p>\n\n\n

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\"Organ-on-chip
The organ-on-chip device under the microscope \u2014 the manufacturing craft behind the science.<\/figcaption><\/figure>\n<\/div>\n\n\n
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PUBLICATIONS<\/h2>\n\n\n\n
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A biomimetic microphysiological system predicts the impact of sepsis therapeutics on neutrophil\u2013endothelial dynamics.<\/strong><\/p>\n\n\n\n

Lab on a Chip, July 2026<\/p>\n\n\n\n

A microvascular chip that predicts which sepsis drugs actually calm the immune response at the vessel wall.<\/em><\/p>\n\n\n\n

organ-on-chip \u00b7 sepsis \u00b7 neutrophil\u2013endothelial<\/p>\n\n\n\n

https:\/\/doi.org\/10.1039\/d6lc00347h<\/a><\/p>\n<\/div><\/div>\n<\/div>\n\n\n\n

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Prioritizing FDA approved therapeutics for treating sepsis phenotypes: A network modeling approach based on neutrophil proteomics.<\/strong><\/p>\n\n\n\n

Frontiers in Immunology, August 2025<\/p>\n\n\n\n

Network modeling on neutrophil proteomics ranks existing FDA-approved drugs by sepsis phenotype \u2014 a repurposing shortlist.<\/em><\/p>\n\n\n\n

proteomics \u00b7 network modeling \u00b7 drug repurposing<\/p>\n\n\n\n

https:\/\/www.frontiersin.org\/journals\/immunology\/articles\/10.3389\/fimmu.2025.1646141\/full<\/a><\/p>\n<\/div><\/div>\n<\/div>\n\n\n\n

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The critical role of neutrophil-endothelial cell interactions in sepsis: new synergistic approaches employing organ-on-chip, omics, immune cell phenotyping and in silico modeling.<\/strong><\/p>\n\n\n\n

Frontiers in Cellular and Infection Microbiology, January 2024<\/p>\n\n\n\n

Maps how neutrophil\u2013endothelial crosstalk drives sepsis and where organ-on-chip, omics, and modeling combine.<\/em><\/p>\n\n\n\n

sepsis \u00b7 organ-on-chip \u00b7 omics<\/p>\n\n\n\n

https:\/\/www.frontiersin.org\/journals\/cellular-and-infection-microbiology\/articles\/10.3389\/fcimb.2023.1274842\/full<\/a><\/p>\n<\/div><\/div>\n<\/div>\n<\/div>\n\n\n\n

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CONNECT<\/h2>\n\n\n\n
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danliu.bio<\/a><\/div>\n\n\n\n
LinkedIn<\/a><\/div>\n\n\n\n
ORCID<\/a><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Dan Liu I build the devices behind the science. Presidential Fellow, Temple University \u00b7 PhD Candidate in Bioengineering ABOUT I build microphysiological systems \u2014 organ-on-chip platforms \u2014 that model human vascular biology for drug discovery. Before returning for the PhD, I spent 10+ years in pharma \u2014 process engineering, product management, CMC business development, and … <\/p>\n

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