Metastatic Tumor Cells 1

Highly metastatic MDA-MB-231 tumor cells reduced endothelial cell adherens junction (VEcadherin)
molecule expression. When cultured without the presence of tumor cells, adherens junctions were
fully established between adjacent cells. When co-cultured with MDA-MB-231 tumor cells, VE-cadherin was
partially expressed between adjacent cells, while no change in VE-cadherin expression was observed when
HBTAEC were co-cultured with MCF-7 tumor cells. Cell adherens junction molecule was stained with VEcadherein
antibody (red); cell F-actin microfilament was stained with phalloidin (green); cell nucleus was
counterstained with Hoechst 33342 (blue).

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