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Permeability of HBTAEC

Permeability of HBTAEC increased significantly with increasing co-culture duration with highly metastatic MDA-MB-231 cells (panel A) and was accompanied by morphological changes in endothelial cells (panels B–D). HBTAEC cultured without tumor cells showed no change in morphology for 120 h (panel B) but endothelial cell morphology changed significantly when co-cultured with MDA-MB-231 cells for 120 h (panel C). HBTAEC co-cultured with MCF-7 cells for 120 h showed fewer morphological changes (panel D). Data are presented as mean ± SEM (n = 3). *Significant difference by two-way ANOVA.