Current Research Projects

Research in the Andrade Laboratory is inspired by Nature’s unrivaled capacity to produce myriad, complex chemical structures that possess unique biological activities.  We develop novel synthetic methodology to efficiently prepare structures of interest (i.e., synthesis), interrogate their molecular mechanisms of action in biological systems (i.e., chemical biology), and apply our findings to develop therapeutics (i.e., medicinal chemistry).

Current projects include the discovery of (1) Synthesis of novel antibiotics that address the problem bacterial resistance and (2) indole alkaloids that combat cancer via unique mechanisms of action.

1 Total Synthesis of Albocyline and Its Analogues

2 Total Synthesis of Bioactive, Structurally Complex Indole Alkaloids

1) Total synthesis of (-)-melodinine K

2) Total synthesis of ibogamine

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